Comparison of Alopecia Areata Induction in C3H/HeH Mice by Injection of Lymphocytes from Mice with Induced vs. Spontaneous Disease

April 2017 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

G.M. DelCanto, Allison L. Bayer, Karen Pérez de Alejo, C. Cabello Kindelan, Assuan Lens, Javier Jiménez

alopecia areata C3H/HeH mice lymphocytes T lymphocytes flow cytometry AA

TLDR Both induced and spontaneous AA lymphocytes can cause alopecia areata in mice.

This study compared the effectiveness of inducing alopecia areata (AA) in C3H/HeH mice using lymphocytes from mice with induced AA versus spontaneous AA. Ten healthy mice were injected with cultured lymph node cells from mice with secondary AA, and another group received cells from mice with primary AA. Initial results at 8 weeks post-injection showed that one mouse from each group developed AA. Flow cytometry indicated no significant differences in T lymphocyte populations between the two groups. The study aimed to determine if secondary AA lymphocytes could reliably induce AA, similar to spontaneous AA lymphocytes, with final results pending after 20 weeks of monitoring.

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