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Glossary C3H mice

specific lab mice strain used in cancer and genetics research

C3H mice are a specific strain of laboratory mice that are commonly used in scientific research. They are known for their susceptibility to developing certain types of cancers and for their use in studies related to immunology, genetics, and aging. This strain is also notable for its distinctive agouti coat color, which is a mix of brown and black fur.

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research 066 Comparison of alopecia areata induction in C3H/HeH mice by injection of lymphocytes from mice with induced vs. spontaneous disease

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study investigates whether lymphocytes from mice with secondary alopecia areata can effectively induce the disease in a C3H/HeH mouse model, similar to lymphocytes from mice with spontaneous disease.

research Physiologic functions of PP2A: Lessons from genetically modified mice

87 citations , July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.

research A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice

60 citations , August 2008 in “Human molecular genetics online/Human molecular genetics”

This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.

research Site of beige (bg) and leaden (ln) pigment gene expression determined by recombinant embryonic skin grafts and aggregation mouse chimaeras employing sash (W^sh) homozygotes

7 citations , October 1985 in “Genetics Research”

This study found that in chimaeric mice models, the pigment distribution and pattern were influenced by the sash genotype, demonstrating the melanocyte-autonomous nature of the beige and leaden loci.

research CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata

64 citations , July 2016 in “Journal of Immunology”

In this study, blocking the CXCR3 receptor in mice prevented the development of alopecia areata by inhibiting the accumulation of specific T cells in the skin, suggesting a potential therapeutic approach for humans.

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