49 citations
,
December 2018 in “JAAD case reports” This case report describes a patient who developed alopecia after 18 weeks of treatment with dupilumab for atopic dermatitis.
49 citations
,
January 2018 in “Immunology” This review discusses the relationship between psoriasis and autoimmunity, focusing on autoimmune co-morbidities, but reports no new research findings.
49 citations
,
September 2008 in “International journal of pharmaceutics” This study suggests that artificial sebum L may serve as an effective substitute for human sebum in drug transport studies, due to its similar physicochemical properties.
47 citations
,
September 2023 in “Pharmacological Reports” In this review, researchers explored the roles of vitamins A, B3, C, D, and E in skin immunity, highlighting their potential as therapeutics for skin diseases due to their antioxidant, anti-inflammatory, and antimicrobial properties.
47 citations
,
November 2012 in “Expert Opinion on Therapeutic Patents” The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
46 citations
,
September 2014 in “Steroids” This review suggests that brassinosteroids may have similar biological activities in both plants and other organisms, prompting further exploration of steroid regulation mechanisms across different life forms.
46 citations
,
September 2011 in “Journal of Endocrinology” This study suggests that 5α-reduced glucocorticoids may have anti-inflammatory potential and could serve as biomarkers for liver inflammation in metabolic disease, with implications for drug development.
46 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Acvr1b signaling is crucial for both hair follicle development and cycling in mice, with the genetic disruption leading to hair loss and a thickened epidermis.
46 citations
,
December 2001 in “Journal of Endocrinology/Journal of endocrinology” This study found that mouse FLRG protein, a secreted glycoprotein, is expressed in certain tissues and plays a role distinct from follistatin during wound healing, suggesting different functions in vivo.
45 citations
,
January 2020 in “International Journal of Molecular Sciences” This review discusses the potential of plant polyphenols to overcome multidrug resistance in various solid cancers and reports no new experimental results; further research is suggested.
45 citations
,
February 2001 in “Joint bone spine” This study found that Turner’s syndrome is associated with significant bone mass decrease due to estrogen deficiency, which can be improved with estrogen therapy, while bone issues in Klinefelter’s syndrome may benefit from early androgen therapy and possibly bisphosphonates.
44 citations
,
April 2015 in “PubMed” This study reports that clinical trials of finasteride for androgenic alopecia provide insufficient and systematically biased safety data, with most participants unrepresentative of those in pivotal trials that led to FDA approval.
44 citations
,
January 2007 in “Biological & pharmaceutical bulletin” This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.
43 citations
,
March 2009 in “Journal of Cellular and Molecular Medicine” This study suggests that TGF-β 2 plays a critical role in hair follicle morphogenesis and may enhance the effectiveness of future cell therapies for hair regrowth using expanded dermal papilla cells.
41 citations
,
April 2016 in “Journal of experimental botany” This research suggests that the barley protein RACB supports cell polarity functions rather than interfering with immunity, as it aids nucleus positioning during fungal attack rather than affecting early immune responses.
41 citations
,
July 2015 in “Current Drug Discovery Technologies” This review discusses various plants and herbal formulations traditionally used for hair growth and notes their potential as safer alternatives to synthetic hair loss treatments, but reports no new clinical results.
39 citations
,
January 2019 in “The World Journal of Men's Health” Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.
39 citations
,
November 2016 in “Pharmaceutics” This study found that the contribution of the hair follicle pathway to skin permeation of chemicals can be predicted using lipophilicity, with hydrophilic chemicals showing greater permeation reduction from hair follicle plugging than lipophilic ones.
39 citations
,
March 2008 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.
38 citations
,
July 2021 in “ACS Nano” This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.
38 citations
,
December 2009 in “Therapeutic Advances in Medical Oncology” This discussion proposes a model to incorporate patients with hormone-resistant prostate cancer into the existing framework by redefining hormone resistance and exploring new therapeutic approaches.
38 citations
,
January 2002 in “Biological & Pharmaceutical Bulletin” This study reported that the aqueous ethanol extract of Lygodii Spora demonstrated in vitro testosterone 5alpha-reductase inhibition and in vivo anti-androgenic activity, potentially due to oleic, linoleic, and palmitic acids.
37 citations
,
September 2014 in “Plastic and Reconstructive Surgery” This review discusses available microsurgical reconstructive options for craniofacial surgery and reports no new clinical results; it highlights how innovations in the field have advanced reconstruction techniques.
37 citations
,
April 2012 in “British Journal of Dermatology” This study found that among middle-aged Korean women, those with metabolic syndrome had a higher risk of androgenetic alopecia, while no significant association was observed in men.
36 citations
,
June 2018 in “Journal of The American Academy of Dermatology” This review examines the increasing clinical applications of dermoscopy in diagnosing various skin conditions and highlights its potential to improve diagnostic accuracy and reduce unnecessary histologic confirmation.
36 citations
,
January 2018 in “Burns & Trauma” This review suggests that while NSAIDs may inhibit bone healing and have variable effects on other complications, caution is advised in their prescription post-surgery, particularly for female patients.
36 citations
,
February 2017 in “BMC Complementary and Alternative Medicine” In this study, Geranium sibiricum L. extract promoted hair growth in vitro with human dermal papilla cells and in vivo in mice, outperforming minoxidil by proliferating cells and stimulating growth factor expression, suggesting its potential as a hair growth treatment.
36 citations
,
November 2006 in “Medical Care Research and Review” This review covers the ongoing debate on measuring underinsurance in health coverage and reports no new empirical results, recommending a national effort to standardize underinsurance metrics.
35 citations
,
August 2001 in “Journal of Cutaneous Medicine and Surgery” This paper reviews the use of tacrolimus for various conditions, noting its effectiveness in treating certain skin disorders but highlighting that some findings remain anecdotal due to limited case numbers.
34 citations
,
August 2011 in “Journal of Natural Medicines” This study found that Puerariae Flos extract inhibited testosterone 5α-reductase and promoted hair growth in mouse models, suggesting its potential use for treating androgenic alopecia.