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Significant progress was made in understanding PXE, but effective treatments are still needed.

CaBP1 and CaBP2 are important for maintaining hearing by supporting continuous calcium currents and nerve signaling in the ear.

Mutations in the HEPHL1 gene cause abnormal hair and cognitive issues.

Disrupting the Flcn gene in mice causes early kidney cysts and tumors, which can be treated with rapamycin.

The PP2A-B55α protein is essential for brain and skin development in embryos.

Adult mice with CBS deficiency show minimal health issues and normal lifespan despite high homocysteine levels.

Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.

VDR regulation varies by tissue and is crucial for its biological functions.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

mEphA1 receptor tyrosine kinase is important for skin and hair development and may play a role in certain diseases.

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Knocking out certain genes in mice helps understand skin and hair growth problems.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Blocking a specific protein signal can make hair grow on mouse nipples.

New tools show that in fish, NPY increases feeding and somatostatin decreases it.

Nude mice with grafted human skin developed scars similar to human hypertrophic scars.

Researchers created a new mouse model for studying Citrullinemia Type I and similar conditions, showing symptoms and treatment responses like those in humans.

New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.

Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.

Melatonin directly affects mouse hair follicles and may influence hair growth.

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

Mouse models help understand alopecia areata and find treatments.

Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.

Disrupting Acvr1b in mice causes severe hair loss and thicker skin.

We need better treatments for hair loss, and while test-tube methods are helpful, they can't fully replace animal tests for evaluating new hair growth treatments.

Twist2 is essential for proper skin healing and hair growth in developing mice.

Twist2 is essential for scarless skin healing and hair growth in mouse fetuses.