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Mutations in the enzyme don't significantly change how it binds to its specific substances.

The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.

Old drugs like finasteride and spironolactone are being successfully used for hair loss and skin conditions, and many other drugs show promise for new uses in dermatology.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Androstenedione is better than testosterone for diagnosing PCOS in Indian women.

A baby with maple syrup urine disease improved from skin problems by adjusting his diet to correct amino acid levels.

A woman developed severe kidney injury from using simvastatin with ciclosporin, highlighting the need for careful monitoring when combining these drugs.

Women with effluvium have higher levels of certain urinary steroids, possibly due to stress and increased adrenal activity.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Laser device increases hair density, safe for treating hair loss in men and women.

Finasteride effectively blocks enzyme causing male pattern baldness.

Coal tar shampoos, salicylic acid, and topical corticosteroids are effective for scalp psoriasis, with Vitamin D3 analogues also showing benefits; severe cases may require stronger medication with more risks.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

New antifungal treatments for a children's scalp infection are effective and safe, but it's not decided if they will become the preferred option over the old treatment.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Green tea may help with health issues like cancer, heart disease, and weight loss due to its high catechin content.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Best hair growth results from combining finasteride and minoxidil.

Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.

The document says to treat cat fungal infections with medicine and clean the environment, noting that cats without symptoms can still spread it to humans.

Some birth control pills have a higher risk of blood clots than others.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.