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The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Certain drugs that block specific enzymes can help treat prostate diseases.

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

PPCM microspheres allow controlled finasteride release over 24 hours.

Combining cyclosporine A and ketoconazole can effectively treat anal furunculosis in dogs, with some experiencing recurrences and mild side effects.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Thyroid hormones are important for skin health and changes in them can affect conditions like hair loss and eczema.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.

Ketoconazole shampoo with finasteride improves hair density in men with hair loss.

New compounds may soon be tested to treat excessive hair growth in women.

CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.

Most patients improved with oral contraceptives, but some needed additional treatment.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

The drug combination significantly reduced epileptic drop attacks in patients.

The genes OVOL1 and OVOL2 are important for hair growth and may be involved in a type of skin tumor.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.