Long-Term Control of Epileptic Drop Attacks With the Combination of Valproate, Lamotrigine, and a Benzodiazepine: A Proof of Concept, Open Label Study

April 2011 in “ Epilepsia ”

Vitor Hugo Vaz Machado, André Palmini, Fernanda Almeida Bastos, Rosana Rotert

TLDR The drug combination significantly reduced epileptic drop attacks in patients.

The study evaluated the long-term control of epileptic drop attacks using a combination of valproate, lamotrigine, and a benzodiazepine in 32 patients. Over 12 months, the median number of drop attacks decreased by 96%, with 47% of patients becoming free of drop attacks. Side effects were reported by 68% of patients, including gastric intolerance, tremor, sedation, and hair loss. Despite the open-label design and potential biases, the significant and sustained reduction in drop attacks suggested that this drug combination could be effective and warranted further controlled trials.

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