research Hair Keratin Pattern in Human Hair Follicles Grown In Vitro
Human hair follicles grown in vitro maintain normal keratin patterns and structure.
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research Unraveling the Molecular Mechanisms of Hair and Nail Genodermatoses
Genetic discoveries are key for understanding, diagnosing, and treating inherited hair and nail disorders.
research Scalp Biomarkers During Dupilumab Treatment Support Th2 Pathway Pathogenicity in Alopecia Areata
Dupilumab treatment reduces Th2-related markers and helps hair growth in alopecia areata, showing Th2's role in the condition.
research The Hair Shaft: Normality, Abnormality, and Genetics
Hair microscopy is useful for diagnosing hair disorders, but clear definitions are needed for accurate genetic analysis.
research Strategies for Improved Hair Binding: Keratin Fractions and the Impact of Cationic Substructures
Certain treatments can increase protein binding to natural hair but are less effective on permed hair.
research Monilethrix
A 12-year-old girl was diagnosed with monilethrix, a genetic condition causing fragile, beaded hair that breaks easily, with no effective treatment available.
research Coenzyme Q10 Has Anti-Aging Effects on Human Hair
Coenzyme Q10 helps reduce aging in human hair.
research Molecular and Cellular Characterization of Avian Reticulate Scales and the Evolutionary Development of Skin Appendages in Foot Soles
Bird foot scales develop differently and can repair but not fully regenerate due to the lack of specialized stem cell areas.
research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin
This study highlights the crucial role of ligand-independent actions of the vitamin D receptor (VDR) in maintaining hair cycle and skin homeostasis. In VDR-KO rats, which lack the VDR gene, there is significant alopecia and skin abnormalities, including hyperkeratosis and increased trans-epidermal water loss. In contrast, rats with a mutant VDR (R270L/H301Q) that cannot bind ligands do not exhibit these issues, indicating that VDR's non-liganded actions are essential. The study found that VDR-KO rats have altered gene and protein expression, particularly in the Shh, Wnt, and Bmp signaling pathways, with decreased hair keratins and increased epidermal keratins. These findings underscore the importance of non-liganded VDR in keratinocyte differentiation, proliferation, and cell death in hair follicles and the epidermis.
research Rational Design of Human Hair Keratin-Driven Proteins for Hair Growth Promotion
RK81 can help promote hair growth.
research The Early Region of Trichodysplasia Spinulosa Polyomavirus Drives Proliferation, Altered Differentiation, and Ectopic Expression of Hair Follicle Differentiation Markers in Interfollicular Tail Epidermis
The early genes of a specific virus can cause abnormal skin cell growth and hair follicle changes.
research Histopathological Examination of Hair Matrix Cysts
Hair matrix cysts are rare skin nodules with unique features, often needing surgical removal.
research Chromatin Architectural Protein CTCF Controls Epidermal Barrier Formation, Hair Follicle Fate Maintenance, and Suppresses Inflammatory Responses in the Skin Epithelium
The protein CTCF is essential for skin development, maintaining hair follicles, and preventing inflammation.
research Hair: Worth Its Weight in Gold
Hair is culturally and economically valuable, and its weight is now used to measure the effectiveness of hair growth treatments.
research Office Diagnosis of Hair Shaft Defects
The document explains how to identify different hair problems using a microscope.
research Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis
Mice without certain skin proteins had abnormal skin and hair development.
research Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle
Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.
research Isolation of Intermediate Filament Assemblies from Human Hair Follicles
Researchers isolated and identified structural components of human hair follicles, providing a model for studying hair formation.
research The Susceptibility of Disulfide Bonds to Modification in Keratin Fibers Undergoing Tensile Stress
Disulfide bonds in keratin fibers break more easily under stress, especially when wet, affecting fiber strength.
research Monilethrix: A Rare Inherited Hair Shaft Disorder in Siblings
Monilethrix is a genetic hair disorder causing fragile, beaded hair with no effective treatment.
research Human Hair Keratin Gradient Metallogel and Their Applications for Wound Healing
The research developed a human hair keratin and silver ion hydrogel that could help heal wounds.
research Structure–Property Relationships of Meta-Kerateine Biomaterials Derived from Human Hair
Protein composition greatly affects the function of keratin biomaterials.
research Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces
Coating surfaces with human hair keratin improves the growth and consistency of important stem cells for medical use.
research Development of a Mechanically Stable Human Hair Keratin Film for Cell Culture
A new film made from human hair supports skin cell growth better than collagen.
research Adsorption of Diclofenac and PFBS on a Hair Keratin Dimer
Human hair keratin might be good for filtering out harmful substances from water.
research The Use of Keratin Biomaterials Derived from Human Hair for the Promotion of Rapid Regeneration of Peripheral Nerves
Keratin from human hair helps nerves heal faster.
research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia
Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.
research Review: Evolution And Diversification Of Corneous Beta-Proteins, The Characteristic Epidermal Proteins Of Reptiles And Birds
Corneous beta-proteins evolved uniquely in reptiles and birds, forming scales, claws, beaks, and feathers.
research Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation
Without keratin 10, there's more growth and development of oil-producing skin cells.
research Is Thyrotropin-Releasing Hormone a Novel Neuroendocrine Modulator of Keratin Expression in Human Skin?
Thyrotropin-releasing hormone may help control skin and hair growth and could aid in treating related disorders.