Insights Into Structural and Proteomic Alterations Related to pH-Induced Changes and Protein Deamidation in Hair

    November 2024 in “ International Journal of Cosmetic Science ”
    Sunil S. Adav, Alicia Rosabee Yu Ling Wu, Kee Woei Ng
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    TLDR Haircare products with a pH between 5 and 7 are best for maintaining healthy hair.
    This study investigates the effects of varying pH levels on hair structure and proteins, using scanning electron microscopy and mass spectrometry-based proteomics. It finds that extreme acidic (pH 3) and alkaline (above pH 8) conditions significantly impact hair morphology and proteins, particularly causing deamidation of keratins and keratin-associated proteins. In contrast, pH levels between 5 and 7 have minimal effects, suggesting that haircare products within this pH range are optimal for maintaining hair health. The research underscores the importance of pH in hair care, recommending products with a neutral pH to preserve hair integrity.
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