Insights Into Structural and Proteomic Alterations Related to pH-Induced Changes and Protein Deamidation in Hair

    November 2024 in “ International Journal of Cosmetic Science ”
    Sunil S. Adav, Alicia Rosabee Yu Ling Wu, Kee Woei Ng
    Image of study
    TLDR Haircare products with a pH between 5 and 7 are best for maintaining healthy hair.
    This study investigates the effects of varying pH levels on hair structure and proteins, using scanning electron microscopy and mass spectrometry-based proteomics. It finds that extreme acidic (pH 3) and alkaline (above pH 8) conditions significantly impact hair morphology and proteins, particularly causing deamidation of keratins and keratin-associated proteins. In contrast, pH levels between 5 and 7 have minimal effects, suggesting that haircare products within this pH range are optimal for maintaining hair health. The research underscores the importance of pH in hair care, recommending products with a neutral pH to preserve hair integrity.
    Discuss this study in the Community →

    Research cited in this study

    18 / 18 results

    Related Community Posts Join

    6 / 84 results

      community Does anyone know the chemical formula for pelage pp405?

      in Research/Science  14 upvotes 7 months ago
      The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

      community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

      in Progress Pictures  492 upvotes 3 years ago
      A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

      community New warning by FDA on topical finasteride

      in Research/Science  194 upvotes 5 months ago
      The FDA warned that topical finasteride can cause serious side effects like sexual dysfunction and brain fog, similar to oral finasteride. Compounded topical formulations pose additional risks due to lack of regulation.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 3 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

    Similar Research

    5 / 1000+ results