December 2023 in “The journal of physical chemistry. B (1997 : Online)” This study explored the potential of human hair keratin as a filtration material, finding that it may effectively absorb the pollutants diclofenac and perfluorobutanesulfonate. The researchers reported significant binding affinities through molecular simulations, supporting further investigation into keratin's use for water purification.
October 2023 in “arXiv (Cornell University)” This study investigated the ability of a human hair keratin dimer to absorb the pollutants diclofenac and perfluorobutane sulfonate, finding high binding affinities that suggest potential for hair-derived materials in water filtration technologies.
13 citations
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November 2007 in “Journal of Structural Biology” Keratin heterodimers are preferred for their specific and structural advantages.
28 citations
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March 1993 in “Journal of Cell Science” In this study, rabbit esophageal epithelial cells were found to produce K4 and K13 keratins in suprabasal cells, forming disulfide-crosslinked dimers that may support the physical stability of the esophageal lining.
10 citations
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January 1989 in “Archives of Dermatological Research” The method effectively analyzes human hair proteins, especially nonfilamentous ones.
42 citations
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July 2015 in “PLoS ONE” This study presents the first detailed 3D models of the complete K1/K10 keratin dimer and identifies structural features and interactions that may inform understanding of keratin filament assembly.
March 1990 in “Journal of Dermatological Science” 55 citations
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January 2013 in “International Journal of Cosmetic Science” In this study, researchers found that higher concentrations of internal lipids in African hair may influence its keratin structure, as observed through various analytical methods.
28 citations
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November 2009 in “Journal of Structural Biology” This study found that the molecular structure of hair is more sensitive to synchrotron X-ray radiation than its supramolecular architecture, indicating potential concerns for biological analyses using such radiation.
12 citations
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January 2014 in “Cell structure and function” This study suggests that specific combinations of human type I and II hair keratins, particularly K35-K85 and K36-K81, have distinct in vitro assembly properties that are significant for macrofibril formation.
99 citations
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July 2012 in “PLoS Genetics” This study identified a 69 bp deletion in the KRT75 gene as the cause of the frizzle feather trait in chickens, affecting feather curling.
38 citations
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October 2011 in “Analytical biochemistry” This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.
48 citations
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March 2020 in “Stem Cell Research & Therapy” This study found that human adipose-derived stem cells co-cultured on a collagen sponge scaffold showed increased differentiation into keratinocytes, suggesting potential for improved skin wound healing.
14 citations
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July 2007 in “International Journal of Cosmetic Science” This study found that a new 3D image analysis method from SEM images enables quick and accurate measurement of cuticle scale heights in hair fibers.
11 citations
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January 2013 in “Veterinary dermatology” This study found that a bulge stem cell-enriched population from canine hair follicles successfully formed interfollicular epidermis in vitro within two weeks, suggesting potential for regenerative canine skin therapies.
10 citations
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August 2021 in “Frontiers in cell and developmental biology” This study suggests the possibility of regenerating hair follicle structures in vitro using hiPSC-derived cell composites, which might reduce reliance on human tissue-derived cells for hair bioengineering.
3 citations
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January 1989 in “The Nishinihon Journal of Dermatology” This case report describes a proliferating trichilemmal cyst that underwent malignant transformation, with specific keratins identified in the tumor but no epidermal keratin detected.
1 citations
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April 2023 in “Langmuir” This study used molecular dynamics simulations to model the outer surface of human hair, illustrating complex behavior and potential adsorption interactions with fatty acids, which may inform cosmetic formulation development.
April 2020 in “International Journal of Cosmetic Science” This study found that improved protein extraction methods enhanced the resolution of hair proteins on gels, but differences in protein abundance between curly and straight Japanese women’s hair were minimal and unlikely to affect hair structure.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrated that Tet2 and Tet3 enzymes are crucial for controlling gene expression related to hair differentiation in mice, suggesting DNA demethylation could be a new method for managing hair growth.
4 citations
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January 2021 in “Archives of dermatological research” This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.
January 2012 in “조직공학과 재생의학” This study demonstrated the potential of newly fabricated epithelial cell scaffolds to enhance hair regeneration, showing promise for future alopecia treatments.
June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that a synthetic polyphenol, dimeric 1,2,4-benzenetriol (diBTO), can coat gray hair and gradually oxidize, creating a resistant brown layer similar to apple browning, which offers a practical hair dyeing solution that withstands washing and reduces the need for long dyeing sessions.
51 citations
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September 2012 in “Biomacromolecules” This study found that disulfide bonds in keratin increase its strength and toughness, with some loss of α-helical structure under load, highlighting their role in trichocyte α-keratin's mechanical properties.
10 citations
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November 2013 in “Biochemistry and Molecular Biology Education” This review discusses the history, structure, and biological significance of keratins, including the crystal structure of a keratin helical segment, without reporting new experimental results.
235 citations
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July 1999 in “Journal of biological chemistry/The Journal of biological chemistry” This study establishes a catalog of human type I hair keratins and identifies their specific roles and expression patterns during hair differentiation and growth in scalp follicles.
13 citations
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July 2017 in “Biopolymers” This study presents recombinant human hair keratins K31 and K81, observing novel nanostructures from their self-assembly and emphasizing disulfide crosslinking's role in this process.
66 citations
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June 2004 in “Biophysical Journal” Hard α-keratin in hair has a unique, nonordered structure, different from other fibers.
7 citations
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January 2011 in “Biochemistry Research International” This study confirms that the proposed universal model for hard α-keratin structure applies to all known forms across various mammalian species.