research Whole Exome Sequencing in Alopecia Areata Patients Identifies a Hotspot Mutation in the Type II Hair Keratin Gene, KRT82
A mutation in the KRT82 gene is significantly associated with Alopecia Areata.
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research Efficacy and Safety of L-Cystine Associated or Not to a Natural Keratin (Kera-Diet) Hydrolysate on Hair and Nails: Randomized, Placebo-Controlled, Clinical Trial on Healthy Females
L-Cystine and L-Cystine with Kera-Diet® safely improved hair and nail quality in healthy women.
research A Dermoscopic Clue for the Diagnosis of Traction Alopecia: Peripilar Keratin Casts Case Report
Peripilar keratin casts are a helpful sign for diagnosing traction alopecia.
research Effect of Anti-Keratin Antibody on the Nature of Hair
Anti-keratin antibody from cow milk makes damaged hair stronger and less likely to break.
research Bidirectional Binding Property of High Glycine–Tyrosine Keratin-Associated Protein Contributes to the Mechanical Strength and Shape of Hair
High glycine–tyrosine keratin-associated proteins help make hair strong and maintain its shape.
research Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle
Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.
research Differential Expression of Keratin and Keratin Associated Proteins Are Linked with Hair Loss Condition in Spontaneously Mutated Inbred Mice
The study investigates hair loss in spontaneously mutated inbred C57BL/6 mice, which exhibit a delayed catagen phase in the hair cycle, leading to cyclic alopecia. The research identifies significant differential expression of genes related to keratinization, such as Krt16, Alox15, and Msx2, with Krt6b levels notably higher in hair loss mice across all hair cycle stages. These findings suggest that the abnormal expression of these genes contributes to the hair loss phenotype. The study provides a model for understanding hair loss mechanisms and developing potential treatments for alopecia.
research Downregulation of mRNAs Encoding Keratin-Associated Proteins in the Tongue of Mice Fed a High-Fat Diet
A high-fat diet may weaken tongue structure by reducing certain protein genes.
research Investigation of Human Hair Keratin-Based Nanofibrous Scaffold for Skin Tissue Engineering Application
Human hair keratin was used to create a scaffold that could help with skin repair.
research Author Correction: Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism
research Publisher Correction: Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism
research Mutation Analysis of the Type II Hair Keratin Gene in a Family of Han Nationality with Monilethrix
A specific gene mutation causes monilethrix in this family, and minoxidil treatment improves hair condition.
research Human Hair Keratin Protein, Hair Fibers and Hydroxyapatite (HA) Composite Scaffold for Bone Tissue Regeneration
research Chronological Aging of Human Hair Keratin Fibers
The study examined very long human hair (over 2.4 meters) to understand the natural aging process of hair keratin fibers using various evaluation methods. It found that hair aging begins with the progressive abrasion of the cuticle while the cortex remains unchanged up to about 1 meter from the root, maintaining shine, hydrophobicity, and friction characteristics. Beyond this point, significant cuticle damage occurs, correlating with a decline in ceramides, 18-Methyl Eicosanoic Acid (18-MEA), and keratin-associated protein content. This leads to a noticeable decay in the mechanical and optical properties of the hair. The research provided a detailed time-dependent 'damage scale' of human hair, which could aid in developing new hair care products.
research Ovine KRTAP36-2: A New Keratin-Associated Protein Gene Related to Variation in Wool Yield
The KRTAP36-2 gene in sheep affects wool yield.
research Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice
Mice with human skin protein K8 had more skin problems and cancer.
research Genetic and Biochemical Aspects of the Synthesis of Keratin by Hair Follicles
research Establishment of Individuality and Determination of Inheritance from Hair Keratin Phenotypes in North Indian Population
research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter
The system allows precise control of gene expression in mouse skin, useful for studying skin biology.
research Unique Amino Acid Signatures That Are Evolutionarily Conserved Distinguish Simple-Type, Epidermal, and Hair Keratins
Different keratin types have unique amino acid patterns that are evolutionarily conserved.
research Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
research Keratins and Skin Disease: Genetic and Molecular Roles
Keratin mutations cause skin diseases and could lead to new treatments.
research The Keratins and Their Disorders
Mutations in keratin genes cause cell fragility and various skin disorders.
research The Structure of the Amorphous Matrix of Keratins
Human hair keratin fibers have a detailed nano-scale structure that changes with different conditions.
research Keratin and Skin Disorders
Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.
research The Proteomic Profile of Hair Damage
Bleaching hair damages protein structure, especially keratin, leading to weakened hair.
research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)
The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.
research Keratins: Dynamic, Flexible Structural Proteins of Epithelial Cells
Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.
research Electrophoretic Variability in Human Hair: Comparative Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Body and Head Hair Proteins
Keratin proteins are consistent across different hair types from the same person.
research Fundamental Studies on the Interaction Between Moisture and Textiles. Part X. Moisture Sorption Properties of Wool and Hair Fibers
Wool and hair fibers absorb moisture similarly due to their keratin structure, with the amount of non-crystalline areas affecting the moisture uptake.