41 citations
,
November 2024 in “Molecular Biomedicine” This review discusses the mechanisms and engineering techniques for enhancing the targeted delivery of extracellular vesicles in therapies but reports no new clinical findings; the authors encourage further exploration to advance clinical applications.
41 citations
,
August 2024 in “Drug Delivery and Translational Research” This review discusses the development and applications of microneedles, particularly through 3D printing, highlighting their potential in transdermal drug delivery but reporting no new results.
41 citations
,
March 2017 in “PLoS neglected tropical diseases” This study found that isotretinoin, a drug commonly used for acne, inhibits polyamine transport in Trypanosoma cruzi, leading to trypanocidal effects, and suggests its potential as a treatment for Chagas disease without affecting mammalian cell viability.
39 citations
,
August 2017 in “Colloids and Surfaces B: Biointerfaces” This study found that 50-nm PLGA nanoparticles delivered with iontophoresis enhanced skin permeation of indomethacin in rats more effectively than 100-nm nanoparticles, suggesting improved targeting of hair follicles.
35 citations
,
March 2005 in “Journal of Investigative Dermatology” In this in vitro study, minoxidil, diazoxide, and the novel compound NNC 55-0118 increased hair follicle growth, supporting deer follicles as a viable bioassay for ATP-sensitive potassium channel modulators.
32 citations
,
August 2015 in “Anais Brasileiros de Dermatologia” This review discusses the side effects and diseases related to hairstyles and hair treatments among black women, highlighting the need for thorough examination by dermatologists, but reports no new clinical results.
31 citations
,
August 1975 in “Journal of Pharmaceutical Sciences” This study found that different species metabolized minoxidil into various products, with monkeys and humans showing similar profiles primarily excreting a glucuronide conjugate, while rats and dogs showed distinct differences.
30 citations
,
October 2020 in “Nature Communications” This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.
30 citations
,
June 2017 in “Talanta” This review discusses the critical parameters for MALDI IMS sample preparation in skin analysis and highlights its applications in wound healing, neoplasia, and infection research, but reports no new clinical results.
28 citations
,
May 2020 in “BMC plant biology” This study concluded that GLCAT14A-C genes are crucial for the function of glucuronic acid transfer to AGPs in Arabidopsis, affecting various growth and reproductive traits such as seed germination and root hair growth.
28 citations
,
December 2018 in “Plant, cell & environment/Plant, cell and environment” This study found that the PLC2 gene plays a critical role in auxin-mediated root development in Arabidopsis, influencing root growth and PIN2 distribution.
28 citations
,
December 2010 in “Langmuir” Hair fibers interact through classical forces, which are influenced by treatments and products, important for hair care and other applications.
27 citations
,
August 2018 in “Therapeutic Delivery” In this study, researchers reviewed recent advances in using nanoencapsulation technology to improve the pharmacological treatment of alopecia, suggesting its potential to enhance drug delivery and reduce adverse effects compared to conventional methods.
26 citations
,
June 2011 in “International Journal of Pharmaceutics” This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment.
24 citations
,
April 2007 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that artocarpin delivered via alginate/chitosan microparticles effectively suppressed the growth of hamster flank organs compared to artocarpin in solution form, without significant systemic effects.
22 citations
,
November 2018 in “Brazilian Journal of Pharmaceutical Sciences” This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.
21 citations
,
October 2011 in “PloS one” In this study, researchers identified three molecules in hair that varied with age, suggesting potential markers for aging and targets for cosmetic products.
21 citations
,
July 1988 in “Clinics in dermatology” This article reviews haircare practices and hair cosmetics for patients with alopecia, emphasizing healthy scalp maintenance and caution in styling; it reports no new clinical results.
20 citations
,
September 2018 in “Journal of colloid and interface science” This study found that keratin derivatives with functionalized thiol groups improved binding to both natural and bleached hair fibers, suggesting a promising strategy for enhancing keratin's durability in hair repair.
19 citations
,
July 2018 in “ACS biomaterials science & engineering” This study showed that chemical and mechanical treatments significantly alter the nanoscale surface properties of hair, affecting its roughness, mechanical stiffness, adhesion, and surface potential.
18 citations
,
February 2025 in “Drug Delivery and Translational Research” This study demonstrated that a new topical treatment using ketotifen-loaded microneedles, designed for prolonged release, significantly reduced inflammatory markers in an animal model of allergic conjunctivitis, suggesting enhanced therapeutic delivery and sustained ocular benefits.
17 citations
,
January 2010 in “PubMed” This review explores factors affecting graft growth and survival in hair restoration, emphasizing the importance of fundamental care practices while considering advanced storage solutions and additives, but reports no new findings.
16 citations
,
July 2020 in “Advanced functional materials” This review discusses the development and application of cell-derived matrices in regenerative medicine and disease modeling, presenting various fabrication techniques and future perspectives, but reports no new results.
15 citations
,
November 2017 in “Drug Development and Industrial Pharmacy” This study found that the optimized finasteride-loaded lyophilized tablets using a self-nanoemulsifying drug delivery system improved bioavailability in human volunteers compared to the marketed finasteride product.
12 citations
,
January 2014 in “Cell structure and function” This study suggests that specific combinations of human type I and II hair keratins, particularly K35-K85 and K36-K81, have distinct in vitro assembly properties that are significant for macrofibril formation.
11 citations
,
February 2021 in “Trends in Food Science and Technology” This review explores the potential of edible flowers, particularly the genus Impatiens, for their chemical, nutritional, and bioactive properties but does not report new clinical findings.
10 citations
,
April 2016 in “Research and reports in transdermal drug delivery” This review discusses the potential of follicular drug delivery systems to target the pilosebaceous unit and reports no new research findings.
8 citations
,
July 2020 in “International Journal of Pharmaceutics” In this study, complexation with cyclodextrins was reported to increase the solubility of FIN for potential use in aqueous formulations for treating male androgenic alopecia.
8 citations
,
February 2013 in “Central European Journal of Biology” This article discusses melanocyte development from neural crest cells and reports no new experimental results; the authors suggest a broader range of functions for melanocytes than previously recognized.
6 citations
,
January 2016 in “Springer eBooks” Invasomes effectively deliver drugs through the skin and have potential for improved treatments.