70 citations
,
June 2017 in “Nature Communications” This study introduced a new technique, 2Phatal, enabling precise apoptotic cell ablation in living animals, revealing unique cell-type differences in apoptosis-related dynamics.
68 citations
,
March 2008 in “Experimental dermatology” This study introduced a novel in vitro assay for tracking melanosome transfer between melanocytes and keratinocytes, facilitating the quantification of melanin transfer and supporting the role of filopodia as a conduit.
67 citations
,
June 2019 in “Proceedings of the National Academy of Sciences” This study introduces a method for long-term expansion of adult mouse epidermal stem cells in vitro using an organoid culture system that maintains the basal-apical organization.
61 citations
,
April 2023 in “Advanced Materials” This study introduced a viscoelastic dry electrode that successfully reduces motion artifacts in EP monitoring on hairy skin, maintaining stable performance for up to 48 days.
61 citations
,
June 2022 in “IEEE Journal of Biomedical and Health Informatics” This study introduced a novel deep clustering approach for melanoma detection from dermoscopic images, demonstrating improved performance over existing methods by mitigating class imbalance issues using a center-oriented margin-free triplet loss.
56 citations
,
January 2001 in “Dermatology” This study introduces the concept of teloptosis, which influences hair shedding during the telogen phase and affects hair density, highlighting that early or delayed teloptosis has noticeable effects.
55 citations
,
June 2007 in “Journal of Statistical Planning and Inference” This study introduces an extended approach to the Bonferroni procedure that accounts for correlations among endpoints, aiming to improve test power while maintaining strong control of the family-wise type I error rate in clinical trials.
51 citations
,
September 2020 in “Nucleic Acids Research” This article introduces signatureSearch, a software package designed for gene expression signature searching and functional enrichment analysis, but reports no new clinical results.
47 citations
,
August 2024 in “Science Advances” This study introduces a new biomimetic double wound mask designed to promote scarless healing by coordinating multiple biological pathways and providing enhanced protection and nourishment to wounds.
47 citations
,
November 2021 in “Advanced Functional Materials” This study introduces a novel chitosan-based hydrogel containing cinnamaldehyde-tannic acid-zinc acetate nanospheres, which reportedly enhances wound healing by promoting antibacterial, antioxidant, and anti-inflammatory effects.
44 citations
,
January 2011 in “Journal of Cutaneous Pathology” This study introduces the "HoVert" technique, which generates both vertical and horizontal sections from a single biopsy to effectively differentiate lichen planopilaris from discoid lupus erythematosus in alopecia cases.
40 citations
,
July 2008 in “PROTEOMICS” This study introduced a bioengineered model that simulates acne's microenvironment in mice, enabling the exploration of host and P. acnes interactions and presenting a novel platform for anti-acne drug and vaccine screening.
37 citations
,
December 2014 in “Journal of Biomedical Informatics” This study introduced LabeledIn, a semi-automatic, human-reviewed catalog of drug-disease treatment relationships, highlighting the important role of human input in creating accurate and detailed drug indication resources.
36 citations
,
June 2019 in “eLife” This study introduces MicrobeFDT, a tool that clusters chemically similar compounds and links them to gut microbial enzymes and toxicities, demonstrating its utility by uncovering previously unknown metabolism of the cancer drug altretamine.
36 citations
,
April 1994 in “PubMed” This study introduces a mouse model of cyclophosphamide-induced alopecia, which effectively replicates human chemotherapy-induced hair loss and can be pharmacologically manipulated to study hair regrowth patterns.
35 citations
,
February 2024 in “Science Advances” This study introduces a magnet-assisted fabrication strategy for creating complex 3D soft bioscaffolds, demonstrating its effectiveness by producing structures with overhangs and supporting biohybrid actuators, promising advancements in biomedical applications.
35 citations
,
July 2015 in “Journal of Theoretical Biology” This study introduced a theoretical model suggesting that the morphological transition from bud to cap in tooth germ development is driven by mechanical interactions among cells.
35 citations
,
July 2009 in “Optics express” This study introduces a new intracavity frequency modulation technique for tunable picosecond optical parametric oscillators, enhancing chemical contrast in coherent Raman imaging by allowing real-time subtraction of background signals.
35 citations
,
September 2004 in “American Journal of Dermatopathology” This case report introduces 'onycholemmal carcinoma' as a designation for a slowly growing malignant tumor of the nail bed epithelium in a 69-year-old male, with no recurrence or metastasis observed over four years after treatment.
32 citations
,
January 2016 in “Development” This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.
28 citations
,
February 2016 in “F1000Research” This review introduces an integrated view of hair follicle behavior, highlighting a Yin Yang model of regulation and suggesting glycans as key elements in hair follicle growth control, without reporting new clinical findings.
28 citations
,
March 2014 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” This study introduces the multiple papillary centres model, offering a new explanation for hair twisting by combining known hair morphology features with differential growth rates caused by dermal papillae.
26 citations
,
December 2015 in “Journal of The European Academy of Dermatology and Venereology” This article introduces a new grading system called the FPHL Severity Index to better identify and monitor early stages of female pattern hair loss using clinical criteria.
25 citations
,
October 2018 in “Journal of Mind and Medical Sciences” This review discusses the introduction of new oral anticoagulants for atrial fibrillation and highlights their safety and the development of reversal agents, but reports no new clinical findings.
25 citations
,
April 2007 in “Journal of The American Academy of Dermatology” This article introduces the term "anisotrichosis" to describe the significant variation in hair shaft diameters observed in pattern alopecia, drawing a parallel to anisocytosis seen in blood smears, but reports no new research findings.
24 citations
,
March 2022 in “Genome biology” This study introduces scINSIGHT, a method that showed improved performance over existing approaches in identifying gene expression patterns and cellular processes in heterogeneous scRNA-seq datasets from different biological conditions.
21 citations
,
March 2018 in “Experimental Dermatology” This practical guide introduces methods to study human dermal white adipose tissue but does not report new clinical results, emphasizing available techniques and staining protocols.
21 citations
,
January 2000 in “Aesthetic Plastic Surgery” This study introduced a new classification method for male pattern baldness in Korean men, detailing six types that could guide hair restoration surgery and further research.
20 citations
,
August 2016 in “BMJ Open” This study found that introducing warning symbols and educational programs significantly reduced the erroneous crushing of medications in nursing homes.
18 citations
,
January 2017 in “Dermatologic Surgery” This review examines intrinsic and extrinsic aging impacts and presents evidence-based lifestyle recommendations to complement cosmetic procedures for enhanced antiaging outcomes, but it reports no new clinical results.