TLDR A rare nail bed cancer was successfully treated with no recurrence after 4 years.
The document reported a case of a 69-year-old male with a slowly growing malignant tumor in the nail bed epithelium, which was suggested to be designated as 'onycholemmal carcinoma' due to its similarities with trichilemmal carcinoma. The tumor was characterized by small cysts filled with keratin and atypical keratinocytes penetrating the phalangeal bone. Treatment involved disarticulation of the affected phalanx, and no local recurrence or distant metastasis was observed over a 4-year follow-up period.
119 citations
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January 2000 in “British Journal of Dermatology” Different parts of the nail express different keratins, showing unique patterns of differentiation.
3 citations
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November 2022 in “Frontiers in Medicine” Onychopapilloma likely originates from the nail bed, not the nail matrix.
50 citations
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July 2008 in “British Journal of Dermatology” 138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
36 citations
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December 1991 in “Journal of Dermatological Science” Human nails contain both skin and hair keratins, each needing different extraction methods.
