May 2025 in “The Journal of Rheumatology” This case report describes a woman whose initial presentation of SLE was persistent watery diarrhea, diagnosed as lymphocytic enterocolitis, and shows that immunosuppressive therapy resulted in symptom relief.
In this narrative review, researchers evaluated existing literature on the treatment of frontal fibrosing alopecia, finding that while no curative treatment exists, clinical improvements can be achieved through personalized and combined therapy approaches.
January 2025 in “Hospital Pharmacology - International Multidisciplinary Journal” In this study, researchers explored the effects of various medications on eye health, noting that systemic and local ophthalmic drugs can lead to both widespread and specific ocular side effects, with serious adverse events most associated with neurotropic, immunotropic, and antitumor medications.
January 2025 in “Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)” This study found that cytoplasmic nucleic acids significantly increase the expression of certain chemokines in human keratinocytes through NF-κB activation, though the specific receptors involved remain unidentified.
May 2024 in “Frontiers in Immunology” In this mini-review, recent insights suggest a possible role of type-2-related immunity in diseases like alopecia areata, vitiligo, and localized scleroderma, though whether this immune response benefits or worsens these conditions remains unclear.
December 2023 in “Intisari Sains Medis” This case report describes a 14-year-old female patient with both Systemic Lupus Erythematosus and Diabetes Mellitus, highlighting the rarity of this combination and the importance of thorough evaluation to accurately diagnose and predict the clinical course of the disease.
January 2023 in “Discovery immunology” T cells and bacteria in the gut and skin help maintain health and protect against disease.
October 2018 in “Springer eBooks” The document concludes that various topical medications are effective for skin conditions but often cause skin irritation as a side effect.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that miR-486 may protect against alopecia areata by maintaining hair follicle immune privilege and modulating expression of immune-related genes.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” In a laboratory setting, this study found that Biotrinine® dry extract activated hair follicle growth pathways and increased certain growth factor secretions in human dermal papilla cells, suggesting potential benefits for treating chronic hair loss.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that Ginseng and Albizia extracts, when used together, protected human dermal papilla cells from oxidative stress-induced senescence, and inhibited genes that suppress hair growth, indicating their potential in preventing age-related hair density reduction.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that low-dose blue light (453nm) may positively affect hair growth by interacting with the receptors CRY1 and OPN3 in hair follicle cells.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that mitochondrial dysfunction might contribute to the pathogenesis of Lichen planopilaris by triggering a metabolic shift that leads to chronic inflammation and hair follicle damage.
March 2018 in “Suez Canal University Medical Journal” This review examines targeting the JAK-STAT pathway in inflammatory skin diseases, highlighting existing JAK inhibitors and potential developments, but presents no new experimental or clinical results.
May 2015 in “Journal of The American Academy of Dermatology” There's a growing resistance to the antibiotic mupirocin in children's skin infections caused by MRSA in New York.
January 2025 in “SKIN The Journal of Cutaneous Medicine” This study suggests that while vitamin D3 deficiency is linked to alopecia areata severity, evidence for the effectiveness of supplementation or topical calcipotriol treatment remains inconsistent and low quality.
In this case study, a patient experienced darkening of hair color after taking acitretin, an oral retinoid known for potentially causing alopecia, marking a rare and undocumented phenomenon.
May 2020 in “JAAD case reports” This source describes a previous case report that combined anthralin and calcipotriene to treat alopecia areata, showing promising results, but highlights that further research is needed to understand the mechanisms and potential benefits of this combination therapy.
117 citations
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March 2013 in “Journal of the European Academy of Dermatology and Venereology” This study reported that while no effective treatment exists for frontal fibrosing alopecia, oral 5-alpha-reductase inhibitors showed the most promise, inducing a good clinical response in 45% of patients.
47 citations
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September 2023 in “Pharmacological Reports” In this review, researchers explored the roles of vitamins A, B3, C, D, and E in skin immunity, highlighting their potential as therapeutics for skin diseases due to their antioxidant, anti-inflammatory, and antimicrobial properties.
11 citations
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May 2009 in “Actas Dermo-Sifiliográficas” This review discusses various therapeutic options for alopecia areata and reports no new clinical results; treatments may manage symptoms but do not cure the condition.
11 citations
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January 2009 in “Acta Dermato Venereologica” In this case report, a 37-year-old man with discoid lupus erythematosus experienced around 80% hair regrowth after treatment with a combination of oral and topical therapies.
441 citations
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May 2008 in “British Journal of Pharmacology” This article reviews the potential clinical use of anabolic steroids in treating muscle loss from chronic diseases and aging and highlights both the benefits and risks of these substances in sports.
218 citations
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December 2011 in “Advances in Urology” This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.
138 citations
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February 2007 in “European journal of cancer” This review discusses the classification, pathogenesis, and management of skin, hair, nail, and mucosal changes due to EGFR inhibitors, emphasizing the importance of informing patients to improve therapy compliance.
137 citations
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May 1984 in “Journal of Investigative Dermatology” Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.
131 citations
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August 2004 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” This article reviews the complex pathophysiology of polycystic ovary syndrome, highlighting how genetic, hormonal, and environmental factors contribute to its diverse symptoms, and reports no new results.
105 citations
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May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that activation of the TRPV3 ion channel inhibits human hair growth by affecting hair follicles and outer root sheath keratinocytes.
100 citations
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June 2011 in “Journal of The American Academy of Dermatology” This study found that a once-daily 5% minoxidil topical foam is as effective as a twice-daily 2% minoxidil topical solution for hair growth in women with androgenetic alopecia, with fewer side effects and greater styling convenience.
86 citations
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June 2017 in “Anais Brasileiros de Dermatologia” This review discusses the role of antioxidants in managing oxidative skin damage and reports no new results, emphasizing the need for understanding their mechanisms, limitations, and risks for safe use.