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Lifestyle changes improve metabolism and fertility in overweight PCOS patients; anti-obesity drugs show potential but need more research.

Advanced human skin models improve drug development and could replace animal testing.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

SHBG may be a useful early indicator and treatment target for PCOS.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.

Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

About 8.5% of women in Salvador, Brazil, have Polycystic Ovary Syndrome.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

A male with aromatase deficiency improved bone health with estradiol treatment.

More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.

Skin organoids are a promising new model for studying human skin development and testing treatments.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.