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This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.

This study found that glioblastoma cells express key enzymes involved in androgen synthesis, suggesting these enzymes might be potential targets for new therapeutic strategies.

This study found that manipulating neuroactive steroids during early development stages in male rats influences alcohol-induced locomotor sensitivity, suggesting their role in addiction vulnerability.

Finasteride reduces certain behaviors caused by D1-like receptor agonists but not by D2-like receptor agonists in mice.

Early-life neurosteroid changes affect adolescent exploration and adult behavior.

This review assessed randomised clinical trials on the efficacy and safety of topical and systemic JAK inhibitors for alopecia areata, finding significant hair coverage improvement with ritlecitinibe and baricitinibe, though prolonged treatment is often needed to maintain results.

This study suggests that the phytochemical characteristics of their extract may help reduce IL-1α levels, potentially offering therapeutic support for addressing certain types of nonscarring hair loss.

This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.

A new compound that could treat various androgen-related conditions was created and analyzed.

In a laboratory setting, this study reported that the n-butanol fraction of Urtica laetevirens Maxim. water extracts significantly inhibited 5α-reductase activity.

This study found that midazolam improved PTSD-associated behavioral deficits in rats through its action on the TSPO, CBR, and neurosteroidogenesis pathways.

This study found that volatile organic compounds from Bacillus subtilis strain WM13-24 enhanced root development in Arabidopsis and its host plant through auxin signaling.

This study found that strigolactone biosynthesis and signaling components in soybean may interact with other hormone pathways, influencing soybean development and nodulation.

This study found that ACOD1 deficiency in dermal papilla cells promotes mitochondrial dysfunction and contributes to cellular senescence in androgenetic alopecia, suggesting ACOD1 as a potential therapeutic target and 4-octyl itaconate as a promising treatment option for AGA.

This study found that lateral root formation in plants in response to L. bicolor volatiles involves complex signaling processes, potentially including unknown proteins, CRKs, and ABA pathways.

This study found that extracts from Calotropis gigantea and Tridax procumbens individually demonstrated greater anti-inflammatory activity than Ibuprofen in a carrageenin-induced paw edema model.

This paper discusses a structure-based analysis to find new BRD4 inhibitors, identifying finasteride and amentoflavone as promising candidates for BET inhibition.

This study identified a new enzyme, skin l‐tryptophan‐2,3‐dioxygenase, that may play a role in rat hair growth regulation, showing increased activity during peak hair growth periods.

This study found that estazolam improved PTSD-like behavior deficits in an animal model, which was linked to increased allopregnanolone levels in specific brain regions.

ASLAN004 was safe and well-tolerated, supporting further development for treating certain diseases.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

A neurosteroid can reduce caffeine-induced anxiety in rats.

In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.

This study suggests that the progesterone metabolite allopregnanolone and progesterone regulate distinct gene sets involved in glioblastoma cell proliferation, with some overlapping effects modified by finasteride.

This study found that the progesterone metabolite 3α-THP increased the proliferation and gene expression of human glioblastoma cells, suggesting a role in tumor progression.

This study reports that baricitinib was more effective than placebo in promoting hair growth in adults with severe alopecia areata after 36 weeks of treatment in clinical trials.

This study identified compounds from Laportea bulbifera with potential inhibitory effects on human steroid 5α-reductase 2, suggesting their application in treating benign prostatic hyperplasia.

This study found that silencing IGFBP5 reduced neurotoxicity and motor deficits in the 6-OHDA model of Parkinson's disease, likely by affecting the SHH signaling pathway, suggesting its potential role in mitigating Parkinson’s-related neuronal damage.

This study suggests that dietary decanoic acid may manage hyperandrogenism and insulin resistance in PCOS, as observed in animal and cell model experiments.

This study found that progesterone protects rat Purkinje cells during oxygen-glucose deprivation by activating GABA A receptors through its metabolite, allopregnanolone.