Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-Methylpregna-4,6-Diene-3,20-Dione

The document detailed the creation and crystal structure analysis of a novel antiandrogen compound, potentially useful for treating conditions like prostate cancer, hirsutism, acne, seborrhea, androgenic alopecia, and benign prostatic hyperplasia. The synthesis was depicted in Scheme 1, while X-ray diffraction was employed to determine the crystal structure, revealing a molecule with three six-membered rings and one five-membered ring, along with normal bond lengths, angles, and van der Waals distances. Two C-H···O intermolecular interactions were noted, laying the groundwork for the compound's possible therapeutic use in androgen-dependent diseases.