Anti-Inflammatory Activity of Calotropis Gigantea and Tridax Procumbens on Carrageenan-Induced Paw Edema in Rats
January 2009
in “
OpenSIUC (Southern Illinois University Carbondale)
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TLDR Calotropis gigantea and Tridax procumbens extracts reduce inflammation more effectively than low-dose Ibuprofen.
The study evaluated the anti-inflammatory effects of Calotropis gigantea and Tridax procumbens extracts on carrageenin-induced paw edema in rats, comparing them to the standard drug Ibuprofen. Ibuprofen at a dose of 200 mg/kg body weight significantly reduced paw edema. The extracts of C. gigantea (600 mg/kg) and T. procumbens (400 mg/kg) individually showed 20-35% more anti-inflammatory activity than 50 mg/kg of Ibuprofen. Additionally, combining these plant extracts with various doses of Ibuprofen resulted in greater anti-inflammatory effects than Ibuprofen alone.
