Anti-Inflammatory Activity of Calotropis Gigantea and Tridax Procumbens on Carrageenan-Induced Paw Edema in Rats

    January 2009 in “ OpenSIUC (Southern Illinois University Carbondale) ”
    Sudhir Kumar Awasthi, Mohammad Irshad, M. Moshahid A. Rizvi
    TLDR Calotropis gigantea and Tridax procumbens extracts reduce inflammation more effectively than low-dose Ibuprofen.
    The study evaluated the anti-inflammatory effects of Calotropis gigantea and Tridax procumbens extracts on carrageenin-induced paw edema in rats, comparing them to Ibuprofen. Ibuprofen at 200 mg/kg bw significantly reduced paw edema. The extracts of C. gigantea (600 mg/kg bw) and T. procumbens (400 mg/kg bw) individually demonstrated 20-35% more activity than 50 mg/kg bw of Ibuprofen. Additionally, combining these extracts with various doses of Ibuprofen resulted in greater anti-inflammatory effects than Ibuprofen alone.
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