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In this study, researchers using a Treg-specific HuR-deficient mouse model found that the RNA-binding protein HuR is crucial for stabilizing Foxp3 mRNA, affecting Treg function and immune regulation, with HuR disruption leading to impaired Foxp3 expression and potential autoimmune dysfunction.

This review synthesizes recent research to propose a precision framework for treating androgenetic alopecia and alopecia areata based on genetic insights and pathway biology, highlighting the roles of androgen-receptor signaling, immune dysregulation, and emerging therapies like regenerative medicine and AI-assisted diagnostics.

This review integrates studies on mouse models and human clinical observations to highlight the role of immune cells in skin development and how their dysregulation leads to skin disorders, suggesting potential therapeutic pathways for skin regeneration.

This review discusses the role of immune cells in the pathogenesis of alopecia areata and highlights emerging immunomodulatory strategies and novel therapeutic targets aimed at offering more effective and durable treatments for this autoimmune hair loss disorder.

In a keratinocyte-specific knockout mouse model, this study found that deleting GRK2 disrupted hair follicle homeostasis, causing cyst-like structures, abnormal growth patterns, and eventual hair loss, suggesting potential links to immune-mediated alopecias.

This study describes the case of a 22-year-old female with alopecia areata linked to vitamin D deficiency, highlighting the importance of early diagnosis and management of deficiency to prevent broader health issues.

According to this worldwide systematic review, psoriasis is a prevalent disease with adult prevalence ranging from 0.53% to 11.48%, more common in older populations and with substantial knowledge gaps in low and middle-income countries.

This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.

This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.

This review discusses the complex role of the immune system in tissue repair and regeneration, highlighting its positive and negative influences but reports no new clinical findings.

This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.

This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.

This study observed that alopecia areata can be induced and serially transferred in C3H/HeJ mice using skin grafts, providing a useful model for studying the disease in humans.

This article reviews the recognition and management of Staphylococcus aureus toxin-mediated diseases, but it does not present new research findings.

This study demonstrated that stress inhibited hair growth in mice, likely through substance P-dependent activation of immune cells, highlighting a brain-hair follicle connection.

This article explores the dynamic and energy-efficient nature of telogen hair follicles, challenging the notion of dormancy, and highlights their potential in advancing treatments for hair growth disorders.

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.

This review discusses the complex pathophysiological and clinical aspects of COVID-19, including dermatological findings and their association with SARS-CoV-2 infection but reports no new clinical results.

This review examines testosterone's role in male health and aging but reports no new clinical results; the authors highlight the need for further research on optimal testosterone levels to prevent age-related conditions.

This review discusses the multiple layers of environmental controls on hair stem cell homeostasis and suggests that targeting these layers could offer safer regenerative medicine therapies without directly using stem cells.

This review discusses the role of the skin microbiome in the pathogenesis of various skin disorders, such as atopic dermatitis and psoriasis, and reports no new clinical findings; it emphasizes potential therapeutic implications.

This study identified a novel G207E STING mutation associated with severe inflammatory symptoms and suggested that common polymorphisms in TMEM173 and IFIH1 may modify the phenotype in affected individuals.

This review provides a framework for diagnosing acquired scalp alopecias and discusses both non-scarring and scarring types, but reports no new clinical results.

This essay reviews the role of human scalp hair follicles in the "brain-skin connection," highlighting their dual function as targets and sources of neurohormones, without reporting new experimental results.

This study identified overexpression of certain immune-related genes and underexpression of genes in specific signaling pathways in premature androgenetic alopecia, suggesting potential new therapeutic targets.

This review outlines dermatological toxicities associated with targeted cancer therapies and immunotherapies, emphasizing the need for collaborative management by oncologists and dermatologists but reports no new clinical findings.

This review discusses the potential roles of prostaglandin D2 and its receptor CRTH2 in various diseases beyond allergies and asthma and reports no new clinical results.

This review highlights that frontal fibrosing alopecia’s increasing incidence may involve immune, genetic, hormonal, and environmental factors, yet its pathogenesis remains complex and not fully understood.

This study found distinct gene expression patterns in the blood of alopecia areata patients, suggesting involvement of immune processes and new pathways like Wnt signaling and apoptosis in disease pathogenesis.