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This study found that mixtures used in permanent hair dyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not.

This study highlights that while hair follicle cycling is primarily influenced by growth factors like IGF-1 and Wnt signals, the role of cytokines in normal human hair growth and cycling is less understood.

This study found that isolated red light may serve as an alternative for photo-immunotherapy without additional photosensitizers, as it did not reduce keratinocyte differentiation markers or increase photo-oxidative damage, unlike treatment with IL-4 or UVA1/blue light.

This study found that recombinant murine IL-36α increased the number of regenerated hair follicles and accelerated wound healing in a mouse model of wound-induced hair follicle neogenesis.

In this study, a herbal extract mixture significantly reduced IL-1α gene expression in HaCaT cells, suggesting it may aid in the treatment of nonscarring alopecia.

This study found that the IL-33/ST2 axis may protect against skin carcinogenesis by promoting cross-talk between epithelial cells and regulatory T cells to minimize mutations and contain tissue damage.

This meta-analysis found that alopecia areata patients had significantly higher serum levels of IL-6 and TNF-α compared to healthy subjects, indicating a potential role of these cytokines in the condition's pathogenesis.

This study observed that expanding regulatory T cells in the skin of mice with alopecia areata did not reverse the condition, indicating that additional immunotherapy may be necessary.

This study suggests that IL-4 and IL-13 may play a role in the immunopathogenesis of alopecia areata in some patients, indicating a possible Th2-driven pathway in this condition.

This pilot study found a correlation between individual genetic inflammation profiles and the effectiveness of PRP treatment for hair regeneration, with differences observed between male and female responses.

This study suggests that IL-17 may play a more significant role than IFN-γ in the pathogenesis of chronic alopecia areata, with increasing severity linked to Th17 lymphocytes and cytotoxic T lymphocyte infiltration.

This review suggests that IL-23 inhibitors may be effective for various non-psoriatic inflammatory skin conditions, but emphasizes the need for further large-scale trials to confirm their efficacy and safety.

This study suggests a potential role for S100A7 and IL-17 in the pathogenesis of lichen planopilaris.

This review examines the role of IL-15 in alopecia areata treatment but reports no clinical results, as there are currently insufficient studies to determine its therapeutic potential.

This report presents a case where multiple steatocystomas appeared in a psoriatic patient during ustekinumab treatment, suggesting the drug may unmask a genetic predisposition to steatocystoma multiplex.

IL-27 may help prevent hair loss by creating immune-suppressing cells.

This study found that patients with alopecia areata had significantly higher serum IL-1R1 levels, IL-1R1 gene expression, and hsa-miR-19b-3p levels compared to healthy controls, suggesting these could serve as diagnostic and prognostic markers for the disease's severity.

This study found that the secretory profiles of adipose-derived stem cells vary between balding and non-balding scalp areas in androgenetic alopecia patients, suggesting involvement of angiogenic and inflammatory processes in the condition's development.

This study found that targeting IL-17 signaling in aged skin reduces inflammation and delays age-related traits, suggesting a potential strategy to prevent age-associated skin ailments.

In this study, a plant extract from Northeastern Turkey demonstrated potential for preventing hair loss by downregulating inflammation and androgen production and promoting hair growth in HaCaT cell models.

This study found that psoriatic skin lesions commonly express the cytokines IL-6, IL-8, and TNF-alpha along with a moderate presence of the antimicrobial protein defensin.

This study found that patients with alopecia areata had significantly higher serum levels of IL-1α compared to healthy controls, with no significant difference observed in IL-1β levels.

This study found that in pregnant rats, the suppression of ACTH responses to IL-1β is linked to the action of endogenous opioids and AP, with AP potentially inducing opioid inhibition through increased pENK-A expression.

This study suggests that low-dose IL-2 and IL-15 may help restore immune tolerance in alopecia areata by maintaining Treg cell function, presenting a potential new treatment strategy.

This study explored IL-17D's role in skin biology and found no significant difference in disease progression between IL-17D KO and WT mice in skin inflammation models, but IL-17D did promote cell migration and modestly accelerated wound healing, suggesting it may influence tissue repair processes.

This narrative review reports that IL-17 and IL-23 inhibitors, while effective for psoriasis and other inflammatory diseases, can cause a variety of skin reactions that resemble primary dermatoses, highlighting the need for careful diagnosis and varied management strategies.

This review synthesizes cases of biopsy-confirmed alopecia areata occurring in patients using IL-17 or IL-23 inhibitors, suggesting the need for increased awareness and further investigation into this rare adverse event.

IL-17 and IL-23 inhibitors may cause hair loss.

This study found that Myrtus communis leaf extract significantly decreased IL-1α and increased VEGF gene expressions in human keratinocytes, which may relate to the plant's traditional uses for hair loss and wound healing, though further research is needed to explore these effects.

In this study, Myrtus communis leaf extract significantly reduced IL-1α expression and increased VEGF expression in human keratinocytes, which the researchers suggest may be linked to its traditional use in treating hair loss and wound healing. Further investigation is needed to clarify its mechanisms.