Correlation Between Individual Inflammation Genetic Profile and Platelet-Rich Plasma Efficacy in Hair Follicle Regeneration: A Pilot Study Reveals Prognostic Value of IL-1α Polymorphism

In a retrospective study conducted by F Rossano et al. in 2016, 41 volunteers (25 men, 16 women) were treated with platelet rich plasma (PRP) for hair follicle regeneration. The study aimed to explore the correlation between the individual's inflammation genetic profile and the efficacy of PRP. After the third month of treatment, a significant increase in hair density was observed in 78% of the subjects. The study found a correlation between the pro-inflammatory cytokine IL-1α polymorphism C>A (rs17561) and responders to PRP treatment. The C/C genotype was found in 66% of responders and only 22% of non-responders. The study concluded that the individual's genetic inflammatory profile, particularly IL-1a, could be used as a prognostic value for PRP efficacy in males, while a negative correlation was observed in females.