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270-300 / 1000+ resultsresearch Accumulation of I131 by the skin and hair of animals and man
Radioiodine-131 significantly accumulates in skin and hair.
research Copper Modulates Mitochondrial Oxidative Phosphorylation to Enhance Dermal Papilla Cells Proliferation in Rex Rabbits
In this study, copper was found to promote the proliferation of dermal papilla cells in Rex rabbits by maintaining the function of the cellular mitochondrial electron transport chain.
research Hair-raising Mysteries of the Inner Root Sheath: Unearthing Treasures in Bald Spots
This review suggests that the inner root sheath of human hair follicles may have broader regulatory roles beyond structural support, potentially impacting processes like folliculogenesis, anagen phase regulation, and immunomodulation.
research SOX18 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/β-Catenin Signaling Pathway
This study observed that SOX18 promotes the proliferation of dermal papilla cells in Hu sheep by activating the Wnt/β-Catenin signaling pathway, suggesting its key role in wool growth.
research Matrix effects and application of matrix effect factor
This commentary discusses the challenges of matrix effects in LC–MS analysis and introduces the concept of a matrix effect factor using stable isotopically labeled internal standards to improve analysis reliability.
research 43696 Early real-world experience with baricitinib in the treatment of severe alopecia areata
This announcement discusses the recent FDA approval of baricitinib for treating severe alopecia areata in adults and reports no new clinical results.
research Isolation and properties of inner sheath cells of hair follicles
research 1335 Maintenance of epidermal progenitor function through the mRNA degradation and translation pathways
This study found that the RNA helicase DDX6 is essential for maintaining self-renewal in epidermal progenitor cells by promoting the translation of proliferation regulators and degrading differentiation-inducing mRNAs.
research The Chinese herb Xiaoaiping protects against breast cancer chemotherapy-induced alopecia and other side effects: a randomized controlled trial
In this study, the use of Xiaoaiping alongside routine chemotherapy improved side effects such as alopecia, nausea and vomiting, diarrhea, and enhanced quality of life in breast cancer patients compared to chemotherapy alone.
research Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice
In a depilated mouse model, this study found that blocking CXCL4 activity with an anti-CXCL4 monoclonal antibody promoted hair growth by inducing an earlier anagen phase, delaying hair follicle regression, and altering expression of genes and proteins related to hair growth and cell proliferation.
research First-line therapy with gemcitabine and paclitaxel in locally, recurrent or metastatic breast cancer: A phase II study
This phase II study found that gemcitabine plus paclitaxel showed promising activity and manageable toxicity as first-line therapy for recurrent or metastatic breast cancer, with a 35% overall response rate.
research Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes
This study found that exosomes derived from mesenchymal stem cells primed with rapamycin significantly enhanced hair regrowth, hair density, and hair follicle development in depilation-induced mice compared to controls, suggesting a potential therapeutic approach for hair loss.
research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity
In this study, researchers explored the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb and discovered unexpected subpopulations of melanocytes, including immature SOX10-negative cells, highlighting potential non-melanogenic roles or transitional migratory functions that require further investigation.
research Index
This abstract is a list of dermatological conditions and treatments without providing new research findings or clinical results.
research Index
This article is a reference guide for various dermatological terms, treatments, and conditions, and reports no new clinical findings.
research Regeneration of a bioengineered 3D integumentary organ system from iPS cells
This study describes a protocol for generating a fully functional 3D integumentary organ system from murine induced pluripotent stem cells, including the formation of hair follicles and sebaceous glands that function in vivo.
research Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation
This study demonstrated that human iPSC-derived melanocytes, when transplanted into mice, can reconstitute pigmented hair follicles and integrate into normal tissue, suggesting their potential as a cellular therapy for depigmentation.
research Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma
This paper reviews adverse events related to hedgehog pathway inhibitors in advanced basal cell carcinoma patients, reporting no new clinical results but aiming to inform healthcare professionals for improved patient care.
research Potent Antioxidative and UVB Protective Effect of Water Extract ofEclipta prostrataL.
This study found that the water extract of Eclipta prostrata L. may protect skin cells against UVB-induced damage, likely due to its antioxidant properties and absorption of UVA and UVB radiation.
research Clinical and microscopic evaluation of long-term (6 months) epilation effects of the ipulse personal home-use intense pulsed light (IPL) device
In this study, a square pulse, low-fluence IPL device used at home significantly reduced terminal hair count by 87% six months post-treatment, with evidence of hair miniaturization similar to professional laser treatments.
research Industry update: the latest developments in the field of therapeutic delivery, July 2018
This industry update reports on various advancements in therapeutic delivery during July 2018, highlighting active mergers, collaborations, and potential developments across fields like gene therapy, immuno-oncology, and rare diseases treatment; however, no new clinical results are presented.
research Melatonin supplement induced the hair follicle development in offspring rex rabbits
This study found that maternal melatonin supplementation improved fur quality in Rex rabbit offspring by increasing hair follicle density and altering melatonin receptor gene expression in several organs.
research Developments at the American Board of Hair Restoration Surgery
This piece describes the American Board of Hair Restoration Surgery's efforts to support and enhance the International Society of Hair Restoration Surgery annual meeting but reports no research findings.
research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor
This study reports that Iressa, an anti-cancer agent, commonly causes acneiform eruptions and xerosis as cutaneous side effects, similar to other agents targeting epidermal growth factor receptors.
research Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production
Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
research eLife assessment: CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells
CaBP1 and 2 are important for maintaining the activity of calcium channels necessary for hearing in inner ear cells.
research Revisión sistemática de los efectos adversos cutáneos causados por fármacos inhibidores de los puntos de control inmunitario: características, manejo y pronóstico
This review discusses the characteristics and treatment recommendations for skin-related adverse effects from immune checkpoint inhibitors in cancer treatment, and notes an observed association with favorable oncology outcomes that requires careful interpretation.
research 74643 Deuruxolitinib improves scalp hair regrowth over time in patients with severe alopecia areata: Pooled analysis of the THRIVE-AA1 and THRIVE-AA2 Phase 3 trials
research The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells
This study found that ruxolitinib modulated inflammatory changes and stimulated growth factor signals by blocking the JAK-STAT pathway in an in vitro model of alopecia areata.