11 citations
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January 2015 in “Journal of cellular physiology” This study suggests that abnormal hair cycles in Hr mutant mice may be caused by HR protein overexpression, which down-regulates miR-31 and increases Tgf-β2 expression.
September 2025 in “Al-Nahrain Journal of Science” In this research, the authors found that green-synthesized zinc oxide nanoparticles (GS-ZnONPs) exhibited antibacterial activity against Staphylococcus species isolated from alopecia patients, but also showed cytotoxic effects on human dermal fibroblast cells at a 400 mg/mL concentration.
178 citations
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October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
7 citations
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June 2015 in “The anatomical record” This study in Hexi cashmere goats found that secondary follicle activity increases with time, and Hoxc13 expression varies significantly across different growth stages, suggesting a role in follicle activity.
November 2025 in “Scientific Reports” In this experimental study, researchers found that Notopterygii rhizoma et radix (Qiang Huo) significantly alleviated psoriasis symptoms in mice and cell models, primarily by modulating the PI3K/Akt/mTOR pathway, indicating potential as a multi-target alternative therapy for psoriasis treatment.
17 citations
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March 2012 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, researchers found that overexpression of the hairless protein in Hr mutant mice disrupts inner root sheath formation by downregulating Dlx3 and associated keratins in hair follicle development.
137 citations
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September 2005 in “Proceedings of the National Academy of Sciences of the United States of America” In this study, researchers found that transgenic expression of the Hairless gene in keratinocytes can restore hair follicle regeneration in Hr-deficient mice by repressing Wise, a modulator of Wnt signaling.
November 2008 in “Central Plains Medical Journal” This study found that combining zinc with topical minoxidil significantly improved curative rates in treating androgenetic alopecia after 9 and 12 months compared to zinc alone.
December 2025 in “Veterinary Sciences” This study suggests that ozone bagging therapy may effectively enhance the healing of chronic distal limb wounds in horses, achieving full wound closure with minimal complications.
This study using zebrafish observed that inherited coping styles had a stronger impact on responses to social defeat stress than social rank, with subordinate fish showing more vulnerability to health impairments, including gut inflammation and skin injuries.
5 citations
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May 2025 in “Chemical and Biological Technologies in Agriculture” This study found that purified humic acids from oxidized coal enhance plant growth by modulating oxidative stress and influencing photobiological processes, with improved root growth and enzyme activity linked to antioxidant and pro-oxidant properties.
August 2023 in “Zenodo (CERN European Organization for Nuclear Research)” 18 citations
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May 2010 in “Zentralblatt für Veterinärmedizin Reihe A” This study concluded that hair zinc levels in weaned male rats do not reliably indicate their overall zinc status, as varying dietary zinc levels produced inconsistent hair zinc concentrations.
May 2026 in “Bioactive Materials” This study reported that in degenerative alopecia, Zn²⁺/Cu²⁺-dependent proteases are downregulated and destabilized, and a specially developed microneedle patch reactivated these enzymes, reduced senescence, and enhanced hair regeneration in an animal model.
This study found a correlation between zinc levels in hair and serum, and alkaline phosphatase activity in acne phlegmonosa and alopecia areata patients.
June 2023 in “Zenodo (CERN European Organization for Nuclear Research)”
July 2026 in “Journal of Nanobiotechnology” This study describes a multifunctional hydrogel system designed to treat androgenetic alopecia by integrating nanozymes for reactive oxygen species clearance and melanin nano photothermal agents to enhance hair follicle health, suggesting potential for multi-target precision therapy and improved hair growth.
3 citations
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February 2013 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” A 6-year-old boy developed excessive hair growth after taking diazoxide for low blood sugar.
October 2024 in “Cermin Dunia Kedokteran” This article discusses the surveillance and spread of hand, foot, and mouth disease in China, Singapore, and Indonesia, and reports no new results, emphasizing the need for improved prevention and management strategies.
In this study, researchers identified that the oncomodulin protein lineage, specifically the gene pvalb8, plays a crucial role in the development and function of auditory hair cells in zebrafish by promoting cell proliferation through the Wnt signaling pathway.
January 1980 in “Excerpta Medica , sole distributors for the USA and Canada, Elsevier North-Holland eBooks” I'm sorry, but I can't provide a summary as I don't have the actual content of the document.
16 citations
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June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that DHHC13 is crucial for hair anchoring and skin barrier function, with its deficiency in Zdhhc13(skc4) mice leading to cyclic alopecia and skin abnormalities due to cornifelin deficiencies.
September 2022 in “International Journal of Health Sciences (IJHS)” This study examined the relationship between zinc status and DNA oxidative damage in patients with hair loss in Duhok, Kurdistan Region-Iraq, highlighting the potential role of zinc deficiency in hair loss.
September 2019 in “Journal of Investigative Dermatology” This study introduced a reproducible human model using 3D-SeboSkin technology to study hidradenitis suppurativa, allowing better maintenance of skin integrity and replication of biomarker expression patterns compared to traditional skin cultures, suggesting its value for further research.
2 citations
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December 2025 in “Gels” This study developed a biomimetic 3D skin model with vascularization potential to assess the impact of nano-zinc oxide (nano-ZnO), finding that nano-ZnO significantly influenced genes related to apoptosis, inflammation, and oxidative stress in skin cells.
January 2018 in “International Journal of Advances in Scientific Research and Engineering” This study presents a new automated method for measuring total phenolic compounds in Ziziphus Jujuba fruit extract, showing high precision and potential applications in health and environmental sciences.
January 2020 in “Skinmed” Zinc levels are not significantly different in people with hair loss conditions like Androgenetic Alopecia and Alopecia Areata.
7 citations
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February 2024 in “ACS Applied Materials & Interfaces” This study found that PEGylated Ag₂S-ZnS@TGA-AA heteronanostructures, activated by light exposure, showed synergistic antibacterial effects against multidrug-resistant bacteria, significantly accelerating the healing of MRSA-infected wounds in comparison to untreated wounds.
October 2025 in “The American Journal of Gastroenterology” In this case report, acute liver failure was attributed to a 34-year-old woman's high-dose zinc supplementation taken for three weeks, illustrating that even commonly used supplements can lead to serious conditions like liver failure.
February 2026 in “Materials” This study evaluated Humulus lupulus (hops) extract in cosmetic formulations and found it to maintain antioxidant and anti-irritant properties, reducing erythema by 10% after three weeks of use, supporting its potential for skin health improvement in plant-based cosmetics.