Photo-Responsive Ascorbic Acid-Modified Ag2S–ZnS Heteronanostructure Dropping pH to Trigger Synergistic Antibacterial and Bohr Effects for Accelerating Infected Wound Healing

The study presents a novel approach using photo-responsive ascorbic acid-modified Ag2S–ZnS heteronanostructures (HNSs) to accelerate infected wound healing. When activated by UV light, these HNSs generate reactive oxygen species (ROS) and release silver ions, creating a weakly acidic environment that enhances antibacterial effects against MRSA and E. coli. This method integrates ROS, Ag+ ions, and pH modulation to provide synergistic antibacterial action and promote wound repair without relying on traditional antibiotics, crucial for combating multidrug-resistant bacteria. The HNSs demonstrated excellent biocompatibility, significantly reducing bacterial viability and promoting wound healing in mice without notable cytotoxicity or hemolysis. The study suggests these HNSs as a promising alternative for treating infected wounds, with potential integration into biocompatible hydrogels for improved therapy.