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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

A patient with Satoyoshi syndrome improved with a treatment combining several medications, including carbamazepine and methotrexate.

COVID-19 may harm male fertility and damage the reproductive system.

The study suggests certain ACE gene variations are more common in women with PCOS and may be linked to increased insulin resistance.

Metformin helps manage diabetes, PCOS, and weight in kids but needs more research for long-term safety.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

Insulin helps heal corneal wounds and nerves in diabetic mice by activating the Wnt signaling pathway.

Finasteride doesn't affect erections much, but may decrease libido in men.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Women with congenital adrenal hyperplasia have lower fertility, but with proper treatment, they can conceive successfully.

The conclusion is that a thorough approach is needed to diagnose and manage hyperandrogenism in teenage girls, recognizing its major psychological and health effects.

Finasteride helps treat prostate issues and may prevent prostate cancer in high-risk men.

Sebaceous glands in our skin, developing during pregnancy and active in puberty, produce sebum for skin lubrication, temperature control, and fighting germs, also help in hormone regulation, and their dysfunction can cause conditions like acne and hair loss.

An apple-based supplement was found to stimulate hair protein production, which may help with hair growth.

The new test can measure very small amounts of testosterone in hair, and grinding the hair up first gives more accurate results.

Some skin diseases and their treatments can negatively affect male fertility.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Women with PCOS have similar bone density to healthy women, but those who are obese have higher bone density at some body sites.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Irregular menstrual cycles in exercising women may be linked to energy deficiency or hormonal imbalances, requiring careful diagnosis for proper treatment.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

PCOS is a long-term condition that needs more research for better understanding and treatment.

Thyrotropin-releasing hormone may help control skin and hair growth and could aid in treating related disorders.

The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.

Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Melanocytes are diverse cells important for pigmentation and skin health, influenced by genetics and environment.