Bone Mineral Density Is Unaltered in Women with Polycystic Ovary Syndrome

October 2018 in “ Hormone and Metabolic Research ”

Mohd Ashraf Ganie, Sumit Chakraborty, Ashish Sehgal, M Sreejith, Devasenathipathy Kandasamy, Manisha Jana, Aafia Rashid

polycystic ovary syndrome PCOS bone mineral density BMD dual-energy X-ray absorptiometry BMI insulin resistance serum testosterone DEXA scan

TLDR Women with PCOS have similar bone density to healthy women, but those who are obese have higher bone density at some body sites.

The study investigated bone mineral density (BMD) in 60 young women with polycystic ovary syndrome (PCOS) compared to 58 healthy controls, using dual-energy X-ray absorptiometry for measurement. Results indicated no significant difference in BMD between the PCOS group and controls. However, obese women with PCOS had significantly higher BMD at certain sites compared to overweight and lean women with PCOS. BMD was found to positively correlate with BMI, but not with insulin resistance or serum testosterone levels. The study concluded that BMI is a key determinant of BMD in women with PCOS, and that BMD does not differ between young women with PCOS and healthy controls. Limitations included a small sample size and the lack of certain assessments, suggesting the need for further research on peak bone mass in women with PCOS across different age groups.

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