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This study found that transgenic mice overexpressing E2F1 in their epidermis developed skin tumors, confirming in vivo that deregulated E2F1 activity can contribute to tumor development.

This study found that conditional expression of TGFβ1 in mice affects epidermal and hair follicle growth, with chronic expression causing severe alopecia and a negative feedback loop involving Smad7.

This study concluded that hair follicle hyperplasia found in pseudolymphomatous folliculitis can also occur in genuine cutaneous lymphomas, potentially as a coincidental result of underlying pathological processes.

This report describes the third known case of lipedematous scalp in a 51-year-old woman, marked by progressive thickening of the scalp without hair loss, and notes its association with early meningitis symptoms.

A new EDA gene mutation was found in a Chinese family with a specific skin disorder.

This study found that transgenic mice expressing IGF-1 in their skin showed significant skin changes, early hair follicle generation, and a higher propensity to develop tumors after chemical promotion, suggesting IGF-1's role in skin carcinogenesis.

This study found that epidermal VEGF is crucial for maintaining skin barrier function in mice and may help explain psoriasis development following skin trauma due to its effects on angiogenesis and hyperplasia.

This study found that surgical removal of adrenal glands resolved clinical signs of adrenocortical tumors and hyperplasias in ferrets, but cortisol levels were not excessively high.

In this study, Brca1(S971A/S971A) mice showed a moderately increased risk of spontaneous tumor formation and defects in DNA damage response, suggesting CHK2 phosphorylation of BRCA1 is crucial for tumor suppression.

This study observed that targeted expression of the neu oncogene in transgenic mice led to significant epidermal hyperplasia and a carcinoma-like appearance, suggesting a crucial role for erbB2 signaling in epidermal proliferation and carcinogenesis.

In a testosterone-induced BPH rat model, this study found that ursolic acid treatment significantly reduced prostate weight and hormone levels, suggesting it may inhibit BPH development.

This research observed that multifocal pseudoepitheliomatous hyperplasia may explain some cases of squamous nests in vulvar lichen sclerosus with lichen simplex chronicus, potentially as a reaction to tissue damage rather than squamous cell carcinoma.

This study found that transgenic mice overexpressing human ATF3 showed hyperplastic and dysplastic changes in epithelial tissues, with a high incidence of oral cancer, suggesting potential oncogenic properties of ATF3.

In this study, low-dose BPA was associated with induced prostatic hyperplasia in rats, potentially mediated by COX-2 and L-PGDS through pathways involving cell proliferation and apoptosis.

This study found that platelet-rich plasma treatment significantly improved erectile function and restored neural structures in aged rats with erectile dysfunction, suggesting potential benefits for geriatric patients.

This study found that overexpression of Gsdma3 in mice led to epidermal hyperplasia, skin inflammation, and hair growth defects, suggesting gain-of-function mutations in Gsdma3 cause these conditions.

This study found that women with nonclassic congenital adrenal hyperplasia (NC-CAH) reported lower sexual function and higher sexual distress compared to those with classic CAH (C-CAH), particularly among those showing signs of androgen excess.

In this review, the authors aim to improve the differential diagnosis between hyperandrogenic PCOS and NCAH, which could lead to more personalized treatment strategies for patients experiencing hyperandrogenism.

In this study, Gsdma1/2/3 knockout mice showed reduced epidermal hyperplasia and inflammation when induced by PMA, which was attributed to decreased EGFR-Stat3/Akt signaling due to a decrease in related ligands.

This study found that age is the most significant risk factor for hemorrhagic cystitis after hematopoietic stem-cell transplantation, with additional risk factors including cyclophosphamide-based prophylaxis and, among male recipients, prostatic hyperplasia.

The study observed that women with congenital adrenal hyperplasia experience more impaired sexual functions and are more often homosexually or bisexually oriented than those with polycystic ovary syndrome.

A man with both skin lesions and lung cancer improved quickly with chemotherapy, suggesting the skin condition might be a reaction to immune system injury.

This report describes two cases of aplasia cutis congenita with hair collar signs and hemangioma, which may suggest neural tube defects, although imaging showed no bone or neural tissue abnormalities.

This report describes a rare case of congenital generalized hypertrichosis terminalis in a six-year-old boy with gingival hyperplasia, a coarse face, congenital hydronephrosis, and a heterozygous deletion on chromosome 17q12.

This case report details a 12-year-old boy from rural south India diagnosed with syringolymphoid hyperplasia, which presented with alopecia and anhidrosis.

This case report highlights the challenges in diagnosing simple-virilizing congenital adrenal hyperplasia, emphasizing the importance of early expert evaluation to prevent irreversible changes such as virilization.

This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.

In preclinical studies, a B-Raf inhibitor called WYE-130600 caused dose-related skin effects in dogs and rats, suggesting potential similar responses might occur in humans.

In this case report, researchers described how autoimmune thyroid disease can obscure primary hyperparathyroidism diagnosis, emphasizing the necessity of combining imaging, cytology, biochemical assessment, and parathyroid scintigraphy for accurate diagnosis.

This study describes a functional disorder in the ovary, known as stromal hyperplasia, characterized by the proliferation of ovarian stroma and luteinization of stromal cells, which is linked to excessive androgen production and elevated testosterone levels.