Coexistence of Angiolymphoid Hyperplasia with Eosinophilia and Pulmonary Neoplasia

January 1987 in “ Journal of The American Academy of Dermatology ”

A Dupré, R. Viraben

angiolymphoid hyperplasia with eosinophilia ALHE eosinophil skin lesions biopsy electron microscopy chemotherapy immunologic injury

TLDR A man with both skin lesions and lung cancer improved quickly with chemotherapy, suggesting the skin condition might be a reaction to immune system injury.

The document described a case of a 58-year-old man diagnosed with angiolymphoid hyperplasia with eosinophilia (ALHE) and oat cell carcinoma of the lung. The patient had abnormal skin lesions and a high eosinophil count, with biopsy and electron microscopy confirming ALHE. After chemotherapy treatment, there was a rapid improvement in both the skin lesions and lung cancer, with the skin manifestations resolving within 2 weeks and the lung changes clearing quickly. The patient passed away with no recurrence of the skin condition, and the authors speculated that the coexistence of ALHE and lung cancer could be coincidental or due to an immunologic injury. They suggested that the quick response to chemotherapy implies that ALHE may be an inflammatory reaction to immunologic injury.