5 citations
,
October 2017 in “Cellular Reprogramming” This research found that inhibiting HSP90 in a murine model increased cellular plasticity, suggesting a potential role for HSP90 in cancer progression through enhanced adaptability to stress.
9 citations
,
February 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses the complexity and genetic organization of human keratin gene clusters and addresses the ongoing need for an updated unified naming system; it reports no new clinical results.
10 citations
,
May 2019 in “Seminars in Cell & Developmental Biology” This review discusses epigenetic mechanisms in tissue repair across species and summarizes recent CRISPR-based technologies as promising tools for studying and enhancing tissue regeneration, but reports no new experimental results.
42 citations
,
January 2014 in “Cold Spring Harbor Perspectives in Medicine” This abstract omits specific findings and does not provide new research results.
36 citations
,
January 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the roles of hypoxia and epigenetics in cellular reprogramming and their contributions to tissue regeneration, reporting no new experimental results.
April 2017 in “Journal of Investigative Dermatology” This study found that hyperproliferative stimuli dysregulated the balance of stem cell divisions in keratinocytes, suggesting potential treatment strategies for both benign and cancerous hyperproliferative diseases.
21 citations
,
December 2017 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that fibroblast behavior switching between proliferation and ECM deposition is vital for dermal architecture, where cell migration is primarily important for tissue repair during wound healing.
13 citations
,
May 2016 in “International journal of biological macromolecules” This study demonstrated that molecular dynamics simulations of keratin could effectively model the mechanical properties of hair, aligning well with experimental data, especially when conducted in vacuum conditions.
July 2024 in “Journal of Investigative Dermatology” Cell movements and forces shape feather growth in chicken skin.
1 citations
,
April 2018 in “Journal of Investigative Dermatology” This study found that Polycomb repressive complex 1 is crucial for skin development and stem cell specification, influencing gene activity beyond its known repressor functions.
2 citations
,
February 2023 in “Transgenic Research” In this study, the presence of the HPV11-E2 protein in transgenic mice was found to increase and vary the expression of a reporter gene in hair follicle bulge regions.
January 2008 in “HAL (Le Centre pour la Communication Scientifique Directe)” This study identified complex regulatory elements and interactions involving the Hr gene and HR protein that are crucial for hair follicle formation and cycling in mammals.
108 citations
,
October 2003 in “Journal of biological chemistry/The Journal of biological chemistry” This study documents that trichohyalin acts as a multi-functional cross-bridging protein in the inner root sheath of mouse hair follicles, enhancing mechanical strength by linking keratin filaments to the cell envelope.
13 citations
,
December 2017 in “Stem cells” This study found that in mice, low-dose irradiation causes stem cells in hair follicles to undergo chromatin alterations, which may eventually lead to long-term functional loss in tissues or organs.
April 2023 in “Journal of Investigative Dermatology” This study explores how chromatin differences between dermal papilla cells and papillary fibroblasts contribute to hair follicle inductivity and investigates the regulatory changes in androgenic alopecia.
May 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This review discusses the role of BMP/Wnt signaling in regulating stem cell homeostasis and activation but reports no new experimental findings.
44 citations
,
May 1997 in “Journal of Biological Chemistry” This study found that regulatory sequences crucial for inducing K6a expression in response to epidermal injury are located in specific upstream regions of the K6a gene in transgenic mice.
3 citations
,
April 2010 in “The FASEB Journal” This study found that estrogen, through estrogen receptors, can regulate the expression of the HOXC13 gene involved in hair follicle development, with MLL3 histone methylase playing a collaborative role.
25 citations
,
October 2005 in “PubMed” This study found that keratin 19 and nuclear galectin-1 binding can transiently express in interfollicular epidermal cells after adhesion, suggesting keratin 19 should not be solely used as a stem cell activity marker.
73 citations
,
September 2016 in “Journal of Translational Medicine” This review discusses the drug repurposing of cardiovascular medications like aspirin and statins for new uses, including potential anti-tumor effects, noting promising experimental outcomes but less conclusive clinical trials, particularly in the field of cancer treatment.
13 citations
,
January 2017 in “Plastic and reconstructive surgery. Global open” This study found that Juvéderm Ultra Plus was safe and effective for correcting severe nasolabial folds in a Chinese population, requiring less volume than Restylane while achieving similar responder rates, with fewer severe treatment site reactions.
9 citations
,
July 2020 in “Experimental Dermatology” This review emphasizes the potential of repurposing topical L-thyroxine for skin ulcers and telogen effluvium and highlights the need for further exploration of its use in dermatology.
9 citations
,
November 2017 in “Dermatologic Clinics” This article reviews botulinum toxin use in men, focusing on anatomical and treatment differences, with no new clinical results.
2 citations
,
August 2022 in “Federal Practitioner” This case report describes a patient with lamotrigine-associated drug-induced hypersensitivity syndrome requiring prolonged and complex treatment, with observed complications including extensive alopecia areata and autoimmune thyroiditis.
2 citations
,
September 2016 in “Journal of evolution of medical and dental sciences” This study found that patients with thyroid dysfunction were more likely to experience skin disorders such as chronic idiopathic urticaria, vitiligo, and alopecia areata compared to a control group.
2 citations
,
July 1999 in “Liver transplantation and surgery” Liver transplant can lead to neurological, pulmonary, cardiovascular, and renal complications, with older patients facing higher risks.
November 2024 in “Cureus” In this case report, a 24-year-old male experienced severe vasoplegic shock after ingesting a large amount of minoxidil solution, requiring an unprecedented 180 hours of norepinephrine support for blood pressure maintenance, highlighting the need for extensive supportive care following minoxidil intoxication.
In this case report, a young female who unintentionally ingested topical minoxidil experienced severe circulatory shock and acute pulmonary edema, emphasizing the need for immediate treatment with fluid resuscitation and vasopressors.
July 1999 in “Liver transplantation and surgery” Oxygen levels can drop during liver transplant if bypass pressures are too high, but other reasons should be checked first.
January 2012 in “Current Therapy In Oral and Maxillofacial Surgery” Endoscopic forehead and brow lifting safely and consistently improves aged eyebrows, but may have complications.