Safety and Effectiveness of Juvéderm Ultra Plus Injectable Gel in Correcting Severe Nasolabial Folds in Chinese Subjects

The study assessed the safety and effectiveness of Juvéderm Ultra Plus injectable gel in correcting severe nasolabial folds (NLFs) in 124 Chinese subjects through a double-blind, randomized trial comparing it with Restylane. Juvéderm Ultra Plus required less volume and had a similar responder rate to Restylane. Both treatments showed significant improvements in NLF severity scores at 6 months, with subject-assessed responder rates being similar. A majority of subjects preferred Juvéderm Ultra Plus, which also had a favorable safety profile with common side effects being mild to moderate. The study concluded that Juvéderm Ultra Plus was safe and effective for treating severe NLFs in Chinese subjects.