1744 citations
,
August 2006 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.
11 citations
,
May 2009 in “Medical Hypotheses” This paper proposes a theory explaining how the normal anabolic effects of androgens lead to structural changes and hair follicle miniaturization, contributing to androgenic alopecia.
17 citations
,
January 1995 in “The American Journal of Medicine” This review discusses the management of androgenic disorders in women, highlighting that treatment is generally more effective than recognized, though improvement may take weeks or months to appear.
October 2025 in “Journal of the Endocrine Society” In this case study, a 62-year-old woman with ovarian hyperthecosis experienced normalization of elevated testosterone levels and improvement in hirsutism and hair loss following bilateral salpingo-oophorectomy.
66 citations
,
January 2000 in “Hormone Research in Paediatrics” This study suggests that the paradoxical effects of androgens on hair growth are due to differential gene expression in hair follicles, possibly established during embryogenesis.
41 citations
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April 2010 in “Gender Medicine” This review discusses the causes, clinical features, diagnostic approach, and treatment options for hirsutism in women, but reports no new findings.
8 citations
,
April 1991 in “European journal of endocrinology” This study found that cyproterone acetate significantly reduced both serum 3α-AdiolG levels and hirsutism scores in women with idiopathic hirsutism, PCOS, or 21-hydroxylase deficiency, suggesting its effectiveness in treating excessive hair growth.
6 citations
,
January 2001 in “Cambridge University Press eBooks” This review discusses how androgen excess in polycystic ovary syndrome can lead to hirsutism, seborrhea, and worsen conditions like androgenetic alopecia and acne, but includes no new research findings.
March 2026 in “Dermatology Online Journal” In this study, androgenetic alopecia was linked to a higher likelihood of hyperlipidemia in both men and women and obesity in women, highlighting it as a potential marker for cardiometabolic risk.
March 2020 in “UTUPub (University of Turku)” This study found that self-reported androgen-driven phenotypes, like balding and finger length ratios, were not associated with cancer aggressiveness or biochemical recurrence in prostate cancer after prostatectomy.
January 2020 in “International Journal of Trichology” This case study reported two instances of female androgenetic alopecia with male pattern reversed after surgical removal of an ovarian tumor.
July 2023 in “Journal of the ASEAN Federation of Endocrine Societies” In this study of a postmenopausal woman with hyperandrogenism, GnRH agonist treatment significantly reduced testosterone levels, suggesting the androgen excess was ovarian in origin and indicating the potential of using GnRH agonists as a conservative treatment option when surgery is not feasible.
March 2012 in “Journal of Pediatric and Adolescent Gynecology” This study found that BMI was the only significant predictor of elevated androgen levels in adolescents with PCOS, and hyperandrogenemia was not linked to a specific PCOS phenotype.
7 citations
,
January 2022 in “Case Reports in Endocrinology” This case series observed that ovarian hyperthecosis can manifest with hyperandrogenism and insulin resistance in postmenopausal women, even when serum testosterone levels are below diagnostic thresholds, suggesting potential gaps in current diagnostic criteria.
20 citations
,
January 2007 in “Fertility and Sterility” This case report highlights that a postmenopausal woman experienced virilization due to unintentional transdermal absorption of testosterone from her spouse's topical androgen via shared washcloths, underscoring the importance of considering exogenous androgen exposure in similar diagnoses.
January 2025 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that insulin resistance is common among Pakistani women with PCOS and is independently associated with increased hyperandrogenism, as indicated by correlations with testosterone levels and other androgenic measures.
21 citations
,
February 2021 in “Frontiers in Endocrinology” This review explores the potential impact of hormonal changes during aging on benign prostate hyperplasia-related urinary symptoms and metabolic syndrome, highlighting the hypothesis of a male PCOS-equivalent but reports no new clinical results.
20 citations
,
January 1998 in “Dermatology” This report highlights a case of acne neonatorum in a newborn boy, linking it to familial hyperandrogenism, and emphasizing the importance of family history and maternal hyperandrogenism in diagnosis.
January 2013 in “Obstetrical & gynecological survey” This review discusses diagnostic and management approaches for hirsutism, emphasizing that most cases are due to polycystic ovary syndrome or obesity-related disorders, with idiopathic hirsutism often treated cosmetically.
2 citations
,
May 2021 in “Journal of the Endocrine Society” This study found that in men with high genetic risk factors for polycystic ovary syndrome, there was an associated increase in obesity, type 2 diabetes, coronary artery disease, and androgenic conditions, suggesting these genetic factors can act independently of ovarian function.
157 citations
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April 1994 in “Clinical endocrinology” Androgens can cause hair growth in some areas and hair loss on the scalp.
April 2005 in “CRC Press eBooks” Excessive androgens in women with polycystic ovary syndrome can lead to excessive hair growth and hair loss, but this might not fully explain these conditions.
10 citations
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May 1995 in “Journal of General Internal Medicine” Most women with excessive hair growth have PCOS; treatment varies and focuses on preventing new hair, with electrolysis as the only permanent removal method.
January 1983 in “Elsevier eBooks” This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.
20 citations
,
January 2012 in “International Journal of Trichology” This study identified polycystic ovarian syndrome as the most common cause of hirsutism among patients and found a positive correlation between hirsutism severity and free testosterone levels.
1 citations
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October 2024 in “JCEM Case Reports” In this case report, a patient with pseudovaginal perineoscrotal hypospadias due to 5α-reductase deficiency presented gender dysphoria, and after genomic sequencing confirmation, injectable testosterone undecanoate treatment successfully developed desired male secondary sexual characteristics.
January 2011 in “Revista Portuguesa de Endocrinologia Diabetes e Metabolismo” This article presents a case of congenital adrenal hyperplasia and myelolipoma in a 56-year-old woman, describing her symptoms and characteristics without offering new clinical results.
32 citations
,
November 1996 in “International Journal of Dermatology” This review discusses the use of antiandrogen therapy in dermatology, covering treatments for conditions like acne, hirsutism, and androgenic alopecia but reports no new clinical findings.
November 2017 in “JAMA internal medicine” This letter to the editor states that the titles of two recent pieces in JAMA Internal Medicine should have included "in Men.
December 2013 in “Macedonian Journal of Medical Sciences” This case report describes a 69-year-old woman with hirsutism and elevated serum testosterone, where surgery resolved symptoms and serum testosterone, suggesting ovarian steroid cell tumor consideration in similar profiles.