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240-270 / 1000+ resultsresearch Hutchinson-Gilford progeria syndrome - A brief introduction
This article reviews treatments for progeria, including aspirin, hydrotherapy, and farnesyl transferase inhibitors, but reports no new clinical results.
research Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis
This study found that trichohyalin, a protein previously thought to be restricted to hair and tongue, is also present in isolated cells within the granular layer and stratum corneum of normal human epidermis.
research The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
This study found that Argireline significantly reduced the depth of periorbital wrinkles in Chinese subjects and improved skin morphology in aged mice.
research A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species.
This study developed a rapid method to extract proteins from human hair, revealing phosphorylation on serine and threonine residues in alpha-keratins and matrix proteins.
research Collagen Involvement in Health, Disease, and Medicine
This chapter discusses various aspects of collagen, proposing "extended collagen carential disease" as a new concept tied to nutritional deficiencies, notably Vitamin C's role in maintaining collagen health.
research Atelocollagen Increases Collagen Synthesis by Promoting Glycine Transporter 1 in Aged Mouse Skin
This study reported that atelocollagen enhances collagen synthesis and reduces oxidative stress in aged skin by increasing glycine uptake through GlyT1, resulting in improved skin elasticity and collagen density in aged mice, with effects superior to glycine alone.
research Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation
This study found that the peptides RMYYY and VMYMI displayed stronger binding energy and more frequent interactions with HPGDS compared to the native inhibitor, suggesting potential as future therapeutic drugs.
research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity
This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.
research The hairless (hr) gene is involved in the congential hypotrichosis of Valle del Belice sheep
This study found that mutations in exon 3 of the hr gene are strongly associated with congenital hypotrichosis in Valle del Belice sheep, suggesting a potential genetic link to the disorder.
research Monilethrix: A Novel Mutation (Glu402Lys) in the Helix Termination Motif and the First Causative Mutation (Asn114Asp) in the Helix Initiation Motif of the Type II Hair Keratin hHb6
New mutations in hair keratin genes cause the rare hair disorder monilethrix.
research Hard Keratin IF and Associated Proteins
research Chirality Effect on Physical and Biological Properties of Peptide-Based Hydrogels
This review analyzed how the chirality of peptide building blocks affects their self-assembly into hydrogels, comparing structural and mechanical properties of homochiral and heterochiral peptides, and discussed potential biological applications of these peptide systems.
research Amino Acid as Hair Repair Agent: Unraveling its Mechanism of Interaction with Keratin
research Identification of a human type XVII collagen fragment with high capacity for maintaining skin health
In this study, researchers identified a collagen fragment, sample-1707, expressed in E. coli, which forms nanofibers and promotes blood clotting, osteoblast differentiation, and skin cell regeneration, making it a promising biomaterial for skin care, with a large-scale production yield of 600 mg/L.
research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle.
In this study, elevated mRNA levels for serine-rich ultra high sulfur proteins were observed during active hair growth phases in mice, particularly in the forming hair structures and upper skin layers.
research In vitro 3D organotypic hair follicle-model for high-throughput substance testing
The researchers reported that hydrogels made from methacrylated glycol chitosan and hyaluronic acid with chondroitin sulfate may be suitable for load bearing soft tissue repair, showing enhanced chondrocyte viability and metabolic activity.
research Structures of three polycystic kidney disease-like domains fromClostridium histolyticumcollagenases ColG and ColH
This study reports that Ca 2+ binding alters the dynamics and surface properties of PKD-like domains in Clostridium histolyticum collagenases, enhancing their stability and potentially aiding in collagen-targeting vehicle development.
research The human tri-peptide GHK and tissue remodeling
This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
research Human keratin hydrogels support fibroblast attachment and proliferation in vitro
research Characterization of dermal type I collagen of C3H mouse at different stages of the hair cycle
This study found that collagen remodeling is more active in anagen-stage skin than in telogen-stage skin in mice, suggesting that collagen modifications may support hair follicle growth and migration.
research Bio‐active designed peptide for hair keratin strengthening
This research reports that KCV and its palmitoylated derivatives show strong effectiveness in strengthening hair proteins, indicating their potential for use in advanced hair care products.
research Hutchinson-Gilford Progeria Syndrome: Premature Aging
This article reviews current understanding of Hutchinson–Gilford Progeria Syndrome and suggests RNA-based treatments show promise, but no new clinical findings are reported.
research Table 1_Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth.docx
This study investigated the effects of a recombinant human collagen complex on hair growth, finding it enhanced survival and function of hair follicle stem cells and promoted hair growth in rat models, suggesting its potential for hair loss prevention and hair health maintenance.
research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle
research Human hair proteins as natural reactive oxygen species scavengers for in vitro applications
This study demonstrated that human hair keratins have strong antioxidative properties, providing protection against oxidative stress in human dermal fibroblasts, suggesting their potential as antioxidizing supplements.
research Self-assembling peptide hydrogel scaffolds support stem cell-based hair follicle regeneration
In this study, the RADA-PRG hydrogel enhanced SKP proliferation, survival, and gene expression, effectively supporting hair follicle regeneration in mice.
research Chirality Effect on Physical and Biological Properties of Peptide-Based Hydrogels
This review investigates how the chirality of peptides affects their ability to form hydrogels, comparing the structural and mechanical properties of hydrogels made from homochiral and heterochiral peptides, and discussing their potential biological applications.
research A Missense Mutation within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis
A specific gene mutation causes woolly hair and hair loss.
research One‐Step Tunable Human Hair Keratin Gradient Hydrogel with Antibacterial Activity for Tissue Engineering (Small 52/2025)
This study reported that hydrogels created from keratins extracted from human hair exhibit antibacterial properties and enhance tissue regeneration, suggesting their potential use in full-thickness skin repair, as demonstrated by increased collagen production and improved healing in vivo.