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The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Myrtle has various health benefits and potential for medicine development.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

PEVs improve minoxidil skin penetration, increasing hair growth.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Treatments for melanin disorders exist, but more effective options needed.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Mint essential oils can kill parasites that cause cystic echinococcosis, with M. pulegium oil being more effective than M. piperita oil.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

Nanoparticles can enter the skin, potentially causing toxicity, especially in damaged skin.