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Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Using stem cells from hair follicles to treat female hair loss is safe and effective after six months.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Sons of mothers with polycystic ovary syndrome (PCOS) have a higher risk of obesity and insulin resistance, possibly due to certain genes and factors passed down from their mothers.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.

A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.

Androgenetic alopecia, or hair loss, is caused by genetic factors and hormones, with different mechanisms in men and women, and can be linked to insulin resistance and polycystic ovary syndrome.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

Early hormones shape sex-specific differences in rat glands.

VDR regulation varies by tissue and is crucial for its biological functions.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.

Formestane is a preferred second-line treatment for advanced breast cancer in postmenopausal women because it's effective and has fewer side effects.

Male hormones control a specific gene in hamster skin, with different hormones having varying effects.

The document concludes that individualized Facial Feminization Surgery plans and comprehensive care are crucial for successful outcomes.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.