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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

The document concludes that various skin conditions have specific treatments, ranging from antihistamines for urticaria to surgery and medication for tumors and chronic skin diseases.

Chemotherapy and radiotherapy can cause skin side effects like rashes, hair loss, and nail changes, which are usually managed with conservative treatments.

Doctors should recognize and treat PCOS early in primary care to manage symptoms and lower risk of other health issues.

Gender-affirming therapy can cause skin issues like acne and hair loss in transgender adolescents, and more research is needed on its dermatological effects.

Menopause worsens skin, hair, and nails, affecting self-esteem and quality of life.

Exosomes from hair papilla cells and the Chinese medicine Liao Tuo Fang can potentially promote hair growth and could be used to develop hair growth drugs.

5-Alpha Reductase Inhibitors are effective for male hair loss and some skin conditions, but their effectiveness in women and safety concerns require careful use.

Vitamin D is crucial for skin health and managing skin diseases.

A 24-month-old Nigerian girl developed early puberty with no family history, needing treatment her family couldn't afford.

Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.

Certain drugs and supplements may contribute to hair loss in the frontal hairline in older women.

Skin problems in the elderly are unique and may indicate other diseases, involving changes in skin, hair, nails, and increased cancer risk.

Excessive hair growth in women, often from high androgen levels, is usually caused by PCOS, and can be treated with hair removal, medication, and possibly weight loss.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

The new rodent model successfully mimics non-lean human PCOS symptoms.

Plant extracts can help prevent hair loss and promote hair growth.

Topical corticosteroids may be a safe and effective treatment for severe alopecia areata in children.

Thyroid disease can cause skin, hair, and nail problems, and treating the thyroid condition often improves these symptoms.

Hormones like androgens, estrogen, thyroid hormones, and stress hormones can contribute to hair loss, and treatments target these hormonal imbalances.

Chronic kidney disease can cause skin problems that affect patient quality of life, and treating these conditions can improve outcomes.

Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.

Ketoconazole is effective for treating various fungal infections and has new uses in dermatology, but oral use can have serious side effects.

Melatonin affects skin and hair color and protects skin cells, with potential benefits for hair growth and skin health.

Natural products may help treat skin inflammation from abnormal adrenal hormones.

PCOS is a condition causing irregular periods, excess male hormones, and infertility, often managed by targeting insulin resistance and specific symptoms.

A toddler with a rare adrenal gland tumor causing male-like physical changes was successfully treated with surgery.