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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Androgens can help prevent memory problems caused by apoE4.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Finasteride may cause long-lasting sexual side effects.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Neurosteroids show promise for treating epilepsy and more research is needed.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.

*Acorus calamus* has many medicinal benefits but needs more safety research.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.