April 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This case study reported significant improvement in autoimmune-related symptoms, including complete hair regrowth, in a patient with systemic lupus erythematosus and alopecia areata after treatment with the LGS Protocol.
20 citations
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June 2020 in “Journal of Advanced Research” This study found that high-dose vitamin A and E supplementation with zinc may improve glycemic control and beta-cell function in patients with type 2 diabetes, compared to no supplements.
January 2022 in “Medical research archives” This article reviews the potential role of vitamin D supplementation as an adjunct to alemtuzumab therapy in multiple sclerosis management, noting its possible benefits for autoimmune comorbidities and patient adherence, but reports no new clinical results.
18 citations
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October 1986 in “PubMed” This study found that alpha-tocopherol acetate did not demonstrate any protective effect against hair loss induced by doxorubicin in patients with solid tumors.
39 citations
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June 2009 in “Oncology” This study observed that high-dose retinol palmitate was well-tolerated in resected stage I lung cancer patients, though it raised concerns about potential impacts on lipid metabolism due to elevated gamma-GT levels and triglycerides.
In this case study, a 19-year-old woman with Henoch-Schönlein purpura, potentially triggered by hepatitis B vaccination, experienced improved symptoms after correcting low vitamin D levels and undergoing tonsillectomy, demonstrating these interventions may benefit similar patients.
The authors concluded that capecitabine and high-dose toremifene may be an effective treatment option for patients unable to undergo anthracycline or taxane therapies, based on one woman's cancer management.
2 citations
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September 2022 in “Frontiers in Nutrition” This study found no significant difference in the persistence of new symptoms or quality of life improvements with 200,000 IU of vitamin D3 compared to placebo in patients post-COVID-19 hospitalization.
This review explores the association between sleep disturbances, obstructive sleep apnoea, and metabolic consequences like Type 2 diabetes, but reports no new experimental results; the authors elaborate on existing knowledge and suggest complex interconnections with fat accumulation and various syndromes.
7 citations
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June 2016 in “Bone Research” In this study, a Chinese Han family with hereditary vitamin D-resistant rickets was found to have a homozygous missense mutation in the VDR gene, and the affected individual uniquely responded well to treatment with oral calcium and low-dose calcitriol.
1 citations
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May 2019 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” In this study, a novel VDR gene mutation was identified in a child with HVDRR, and the researchers observed that high-dose intravenous calcium therapy led to significant and sustained improvement in rickets symptoms.
2 citations
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May 2023 in “Al Mustansiriyah Journal of Pharmaceutical Sciences” This study found that high-dose pterostilbene potentially reduced prostate hyperplasia and had strong antioxidant effects in male rats with benign prostatic hyperplasia, suggesting it might be more effective than vitamin C and resveratrol in similar contexts.
April 2016 in “Journal of Investigative Dermatology” This study found that a single high dose of oral vitamin D reduced UV-induced skin erythema and inflammation in humans by enhancing autophagy, suggesting new clinical avenues for skin repair.
This case study reports that prolonged high-dose vitamin A intake led to multiple adverse health effects in a young man, which mostly resolved after stopping the supplement, although liver changes persisted.
April 2017 in “The FASEB Journal” This study suggests that excess dietary vitamin A may arrest hair follicles in refractory telogen in mice, while adequate levels promote competent telogen, revealing dose-dependent effects on hair cycling.
1 citations
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March 2017 in “Al-maǧallaẗ al-’irāqiyyaẗ li-l-’ulūm al-ṣaydalāniyyaẗ/Iraqi journal of pharmaceutical sciences” This study suggests that using nutrient antioxidants can significantly reduce the dose of prednisolone needed in alopecia areata patients while potentially enhancing hair growth and mitigating side effects.
March 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study suggests that using vitamin A, vitamin E, and vitamin C for two months may enable a reduction in corticosteroid dosage for alopecia areata, potentially mitigating associated side effects.
August 2017 in “Journal of epidemiological research” The researchers reported that cancer incidences are rising over time in developed countries, with potential carcinogenic drivers including advancing age, estrogen, decreasing vitamin D3, and Human Papillomavirus.
52 citations
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August 1993 in “Clinical endocrinology” This study found that intravenous high dose calcium infusions followed by high dose oral calcium effectively treated vitamin D dependent rickets type II, leading to complete biochemical and radiological healing and improved growth in two patients.
1 citations
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November 2024 in “AME Medical Journal” In this case study, scurvy was diagnosed in a middle-aged man on hemodialysis with food insecurity and undetectable vitamin C levels, highlighting the diverse risk factors and persistent challenges in managing vitamin C deficiency among patients with complex medical and social issues.
January 1982 in “Side effects of drugs annual” This review discusses the therapeutic effects of vitamins, highlighting risks such as liver damage from prolonged high doses of vitamin A and hypercalcemia from excessive vitamin D, while noting a case of allergic reaction to vitamin B12.
July 2026 in “IntechOpen eBooks” This research highlights the crucial roles of B vitamins in metabolism, neurological processes, and DNA functions, and describes emerging therapies that enhance vitamin absorption and therapeutic potential.
44 citations
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May 1998 in “PubMed” In this study, a specific retinoic acid receptor antagonist caused severe craniofacial anomalies in mouse fetuses when administered early in pregnancy, but not limb anomalies, highlighting developmental stage-specific roles of retinoic acid.
2 citations
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June 2018 in “Sudan journal of medical sciences” In this case study, a 45-year-old woman's hair loss improved after three months of weekly high-dose vitamin D supplementation, emphasizing the importance of assessing vitamin D levels in patients with hair loss.
May 2022 in “Endocrine practice” This case report illustrates that high-dose biotin supplementation can cause false thyroid function test abnormalities in vitro, emphasizing the need to assess biotin intake before testing.
This review highlights the potential analytic interference of high-dose biotin with immunochemical tests, which may lead to diagnostic errors and suggests pausing biotin consumption before laboratory testing.
151 citations
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June 2010 in “Endocrinology and metabolism clinics of North America” This article compares two rare genetic diseases, vitamin D-dependent rickets type 1 and type 2, focusing on their similar presentations of hypocalcemia and rickets in infancy, but reports no new clinical results.
16 citations
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August 1989 in “PubMed” This study concluded that high-dose oral therapy with L-cystine, gelatin, and vitamin A significantly improved hair growth indicators in patients with diffuse hair loss, with no systemic side effects observed.
18 citations
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November 2009 in “Calcified tissue international” A genetic mutation caused severe rickets and alopecia in an Indian patient, but high-dose calcium and phosphate treatment improved their condition.
October 2024 in “Journal of the Endocrine Society” This study highlights a rare case of vitamin D-dependent rickets type 2A caused by a heterozygous mutation in the vitamin D receptor gene, emphasizing the complexity of managing this condition with high-dose calcium and vitamin D therapy.