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Glossary High-Grade Prostate Cancer

more aggressive, rapidly growing prostate cancer with higher Gleason scores

High-Grade Prostate Cancer refers to a more aggressive and rapidly growing form of prostate cancer, often characterized by a higher Gleason score (typically 8-10). This type of cancer is more likely to spread to other parts of the body and requires more intensive treatment compared to lower-grade prostate cancers.

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Research

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research THERAPEUTIC HOTLINE: Treatment of androgenic alopecia with finasteride may result in a high grade prostate cancer in patients: fact or fiction?

9 citations , September 2010 in “Dermatologic Therapy”

This article concludes that finasteride is a safe treatment for androgenetic alopecia and does not increase the risk of high-grade prostate cancer, despite past concerns from the Prostate Cancer Prevention Trial.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.

research The association of male pattern baldness and risk of cancer and high-grade disease among men presenting for prostate biopsy

3 citations , December 2016 in “Canadian Urological Association journal”

This study suggests that male pattern baldness—especially moderate to severe—is an independent risk factor for prostate cancer and high-grade disease in men undergoing prostate biopsy.

research A Chance Finding of High Grade Prostate Cancer in a 35-Year-Old Male – A Case Report and Outcomes of Robotic Radical Prostatectomy in Young Men with Prostate Cancer

December 2023 in “Research and reports in urology”

This case report from the authors highlights a rare diagnosis of high-grade prostate cancer in a 35-year-old man, showing strong functional recovery and no detectable PSA one year after robotic-assisted radical prostatectomy despite the usual onset being significantly later in life.

research Finasteride-its impact on sexual function and prostate cancer

33 citations , January 2009 in “Journal of Cutaneous and Aesthetic Surgery”

This study found no clear evidence that finasteride negatively affects erectile function, though it does cause a reduction in ejaculatory volume and has potential implications for prostate cancer risk.

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Community Join

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community Should I Seek a Second Opinion on Finasteride at 22?

in Basic Questions 114 upvotes 2 months ago

The user is concerned about hair loss and has been using finasteride and minoxidil. The doctor refused to prescribe finasteride due to a perceived increased risk of prostate cancer, prompting the user to consider seeking another doctor's opinion.

community 18M 8 months progress 40mg daily dut stack

in Progress Pictures 112 upvotes 1 year ago

An 18-year-old is using a high-dose hair loss treatment with 40mg daily dutasteride, finasteride, minoxidil, tretinoin, and topical bicalutamide. Despite health risk concerns, especially liver issues, they report hair regrowth progress and intend to continue the regimen.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community Dermatologist told me to quit fin after turning 40

in Finasteride/Dutasteride 194 upvotes 2 years ago

A dermatologist advised a patient to stop taking finasteride (fin) after turning 40 due to potential risk of aggressive prostate cancer. The patient and others in the conversation debated this advice, discussing the relationship between finasteride, prostate cancer, and hair loss, and considering alternatives like topical finasteride.

community Dermatologist refused to prescribe finasteride due to “new research” on male breast cancer. anyone heard of this?

in Research/Science 54 upvotes 10 months ago

A dermatologist refused to prescribe finasteride due to concerns about recent research linking it to male breast cancer, suggesting a topical alternative with minoxidil instead. The user is advised to seek a second opinion, as the evidence for such risks is inconclusive and the dermatologist's reasoning seems questionable.

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Learn

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learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

Is it dangerous to buy dutasteride without a prescription? Dutasteride is a prescription medicine, and its US label warns about a PSA drop, a higher rate of high-grade prostate cancer in one trial, sexual and breast side effects (the sexual ones may persist after stopping, with dutasteride's role unknown), depressed mood and a new UK class warning about depression and suicidal thoughts, risks in pregnancy and a 6-month blood-donation deferral. Buying from unregulated online sellers adds the risk of counterfeit or contaminated products.
Dutasteride side effects: what the label and studies actually report The Avodart label reports impotence in 4.7% and decreased libido in 3.0% of men in the first six months (1.7% and 1.4% on placebo), with new reports falling after month six; those figures come from BPH trials in older men, and the hair-loss trials in younger men run only six months. The label and studies also flag a PSA drop of about half, a small rise in high-grade prostate cancer in one trial, an observational link to depression, and sexual effects that the label says may persist after stopping.

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Experts

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84
SMP Specialist
Craig Bottomley-High
Studham, England, United Kingdom
13+ yrs

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Craig Bottomley-High