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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

The conclusion is that formalizing how past decisions influence current health technology assessments could improve the credibility and defense of coverage decisions.

High afamin levels are linked to metabolic syndrome and may predict its development in women with insulin resistance.

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

Ziziphus jujuba Mills may have health benefits, but more research is needed to confirm its safety and effectiveness.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.

Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

White wax and policosanol from white wax effectively reduced hair loss and promoted hair growth in mice better than a known hair growth drug.

The PCOSQ-50 is a valid and reliable questionnaire for measuring quality of life in Iranian women with PCOS.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

Ethosomes improve drug delivery through the skin but may have side effects like irritation.

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Many young Australian women think they have PCOS, but only a few are diagnosed correctly, causing unnecessary worry.

The oral glucose tolerance test is effective in detecting abnormal glucose tolerance in Indian women with PCOS.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Stem cells can rejuvenate skin, restore hair, and aid in wound healing.

Bimatoprost can cause longer, thicker, darker eyelashes and eyebrows.

Managing PCOS is hard because it varies a lot, treatments are limited, and there's a lot of false information online.

The 2018 update to the ED care model added a new severity score and stressed a detailed evaluation of both physical and psychological aspects.