Oral Glucose Tolerance Test Significantly Impacts the Prevalence of Abnormal Glucose Tolerance Among Indian Women With Polycystic Ovary Syndrome: Lessons From a Large Database of Two Tertiary Care Centers on the Indian Subcontinent

January 2016 in “ Fertility and Sterility ”

Mohd Ashraf Ganie, Atul Dhingra, Shazia Nisar, Vishnubhatla Sreenivas, Zafar A. Shah, Aafia Rashid, Shariq Rashid Masoodi, Nidhi Gupta

TLDR The oral glucose tolerance test is effective in detecting abnormal glucose tolerance in Indian women with PCOS.

The study investigated the prevalence of abnormal glucose tolerance (AGT) in 1,746 Indian women with polycystic ovary syndrome (PCOS) and the effectiveness of the oral glucose tolerance test (OGTT) in detecting AGT. It was found that 36.3% of the participants had AGT, with varying degrees of glucose intolerance, including 6.3% with diabetes. The prevalence of AGT was higher in older and overweight women. A family history of diabetes was common but did not predict AGT, which was instead associated with higher BMI and waist circumference. The OGTT proved to be a more sensitive method for detecting AGT than fasting plasma glucose alone. The study highlights the need for further research to understand AGT in PCOS and suggests that the OGTT should be used for accurate glucose tolerance assessment in this population.

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