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More high-quality research is needed to recommend flavonoids and saponins for clinical use.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

Oral lichen planus is a chronic disease causing mouth discomfort and sometimes needs immunosuppressive treatment.

Dogs have varying numbers of touch-sensitive Merkel cells in different skin areas, with most in the oral mucosa and facial skin, unrelated to age, sex, breed, or color.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Common hair loss disorders may not need stem cell therapy, but could benefit from other treatments like hair cycle control and immune restoration therapy.

New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

3D-printed membranes with smart sensors can greatly improve tissue healing and have many medical applications.

Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.

PRP therapy is effective for hair regrowth and improving hair quality with minimal side effects.

New nanocarriers improve drug delivery for disease treatment.

High-resolution x-ray images showed three main structures in human hair: medulla, cortex, and cuticle.

PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.

Most patients with hard-to-treat high blood pressure can be managed effectively with various treatments, but no single treatment is perfect.

SLHA can be hard to diagnose and needs teamwork between specialists.

Permanent hair removal is hard, but using longer laser pulses at lower power might improve results.

Managing PCOS is hard because it varies a lot, treatments are limited, and there's a lot of false information online.

The document talks about hard-to-treat and rare acne types, their connection with other health issues, the importance of correct diagnosis, and the challenges in managing them.

Many women with hard-to-treat acne also have PCOS.

Hair transplant can cause hard-to-treat keloids in some patients.

Acromegaly can be hard to diagnose in young women with atypical symptoms, and persistent high phosphate levels should lead to growth hormone testing.

Trichoepitheliomas can be hard to distinguish from other skin conditions and often start in teenage years.

Pseudopelade of Brocq is hard to diagnose and treat, with limited effective options.

The case shows how hard it is to tell apart Multiple Autoimmune Syndrome from other similar autoimmune conditions, but correct diagnosis is key for treatment to work.

Scalp psoriasis is hard to treat and may need various medications.

Skin lymphoproliferative disorders are hard to diagnose and often linked to systemic diseases, but most have a good prognosis with accurate diagnosis.

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

Hair loss in teenagers is hard to treat and lacks a cure, with some treatments available depending on the type of hair loss.

Oral retinoids may help some patients with hard-to-treat lichen planopilaris, but more research is needed.