Localized Syringolymphoid Hyperplasia with Alopecia and Anhidrosis

    July 2001 in “ Journal of the American Academy of Dermatology ”
    Andrea Haller, Esseid Elzubi, Peter Petzelbauer
    TLDR SLHA can be hard to diagnose and needs teamwork between specialists.
    The document described a case of a female patient with localized syringolymphoid hyperplasia with alopecia and anhidrosis (SLHA), marking her as the eleventh reported case. The patient experienced a slowly progressing lesion on her right ankle over 7 years before a diagnosis was confirmed through histopathology, which showed syringotropic T-cell infiltrates. The lesion was characterized by brownish papules forming a hairless, sweatless erythematous patch. The disease's progression and treatment resistance suggested SLHA as a syringotropic variant of mucinosis follicularis, potentially a precursor to mycosis fungoides. Despite a 7-year follow-up, no T-cell lymphoma developed in the patient. The case highlighted the diagnostic challenges of SLHA, necessitating collaboration between dermatologists and dermatopathologists.
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