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The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

Amitraz effectively treated sarcoptic mange in three alpacas.

An imbalance in gut bacteria is linked to skin immune diseases and may affect their outcomes and related health issues.

3D cell-derived matrices improve tissue regeneration and disease modeling.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

Boxer dogs may have a genetic skin condition that worsens seasonally and can be treated with certain medications.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

Finasteride helps induce ovulation in nonresponder PCOS women.

The paper concludes that elderly in India face unique skin challenges and need better dermatological care and awareness.

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

TNF-alpha inhibitors can cause various immune-related skin issues.

Transplant patients on immunosuppressive medications have a higher risk of skin cancer, and managing this involves balancing medication with cancer risk.

Diversifying tea products can boost profits and meet global market demands.

The document concludes that proper diagnosis and individualized treatment are crucial for managing androgenization in women effectively.

Pulsed dye laser and hydrogel dressings effectively treat hypertrophic scars.

Targeting NETs may help reduce fibrosis in Crohn's disease.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

New treatments and diagnostic methods for various animal skin conditions showed promising results.