18 citations
,
January 2013 in “Journal of Investigative Dermatology” WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.
17 citations
,
September 2024 in “Molecules” This literature review compiles and analyzes current research on turmeric essential oil's active compounds, reporting their potential therapeutic applications across various medical conditions due to their unique pharmacological profiles and absence of toxicity.
17 citations
,
April 2021 in “Frontiers in Pharmacology” This review discusses the role of Nrf2 in hearing loss and its potential as a target for developing hearing protection drugs, but reports no new clinical results.
16 citations
,
October 2023 in “Molecular cancer” This study reviews the etiology and treatment of skin cancer, focusing on nanotechnology's role in addressing drug resistance and evaluating nanoparticles' potential to improve treatment outcomes, including overcoming multidrug resistance.
16 citations
,
November 2021 in “Antioxidants” This review examines the role of oxidative stress in male hypogonadism associated with noncommunicable chronic diseases and discusses various management strategies, but it presents no new clinical findings.
15 citations
,
January 2020 in “ILAR Journal” This review discusses the occurrence and impact of background histopathologic changes in nonhuman primate research, emphasizing the importance of understanding these factors to enhance study validity and interpretation.
15 citations
,
April 2016 in “Hormones” This review summarizes the clinical features and molecular causes of Primary Generalized Glucocorticoid Resistance, highlighting new findings from the characterization of mutations in the NR3C1 gene, but reports no new experimental results.
14 citations
,
December 2018 in “The American journal of pathology” This study found that genetic activation of Nrf2 in keratinocytes accelerates wound repair by enhancing cell proliferation and re-epithelialization, suggesting potential use for Nrf2-activating compounds in individuals with impaired healing.
13 citations
,
November 2021 in “Frontiers in Molecular Biosciences” This review discusses the mechanisms of platinum-induced peripheral neuropathy related to reactive oxygen species and explores potential antioxidant therapies and nanotechnology approaches, but reports no new clinical results.
13 citations
,
December 2005 in “Traffic” In this study, researchers found that syntaxin 9, a novel syntaxin family member, interacts specifically with the epidermal growth factor receptor and may influence its transport and signaling in some epithelial cells.
13 citations
,
October 2019 in “Oncology Reports” This review discusses the complex relationship between anabolic substances and colorectal cancer risk, reporting ambiguous findings on their carcinogenic properties, potential synergy with risk factors, and protective roles.
13 citations
,
April 2018 in “Scientific Reports” In this study, genetic variants in the KRT25 and SP6 genes were found to be responsible for curly hair in horses, with the KRT25 variant also causing hypotrichosis due to an epistatic effect.
12 citations
,
May 2019 in “Molecular Medicine Reports” This study demonstrated that Forsythiaside A improved survival and reduced neurological deficits in rats with cerebral ischemic injury, potentially through activating Nrf2 and reducing ER stress pathways.
12 citations
,
January 2016 in “Journal of clinical biochemistry and nutrition” In this study, combining deferasirox with sorafenib significantly reduced liver fibrosis and preneoplastic lesions in rats while also lessening adverse effects compared to sorafenib alone.
11 citations
,
February 2023 in “British Journal of Pharmacology” This study found that ISX9 may activate the Wnt/β-catenin signaling pathway and holds potential as a therapeutic agent for treating alopecia.
11 citations
,
December 2021 in “Journal of Ginseng Research/Journal of ginseng research” This review discusses the chemical composition, potential health benefits, and extraction methods of red ginseng oil, and reports no new clinical results but emphasizes safety and proposed molecular mechanisms.
11 citations
,
May 2013 in “Journal of Investigative Dermatology” KRTAP10 proteins help form the hair shaft's tough outer layer by interacting with specific hair keratins.
11 citations
,
August 2018 in “Endokrynologia Polska” This consensus paper reviews current challenges and recommendations for diagnosing and treating polycystic ovary syndrome, highlighting the utility of the Rotterdam criteria for adults and different criteria for teenagers without requiring polycystic ovaries.
11 citations
,
May 2018 in “Frontiers in plant science” This study found that overexpressing the PCaP2 protein in Arabidopsis enhanced drought tolerance by influencing ABA and SA signaling pathways and regulating root hair growth, suggesting a key role in water deficit response.
10 citations
,
March 2024 in “Endocrine Reviews” In this retrospective review, the author discusses key discoveries in understanding androgen excess disorders like PCOS, focusing on genetic and molecular insights gained from 1965 to 2015.
10 citations
,
August 2023 in “Advanced Science” This review discusses nitric oxide's physiological roles and the development of strategies for delivering it exogenously, without presenting new clinical results.
10 citations
,
March 2021 in “Clinical Cosmetic and Investigational Dermatology” This study found that specific genetic variants in the CYP21A2 and CYP19A1 genes were associated with severe acne vulgaris among Han Chinese, particularly in male patients.
9 citations
,
August 2024 in “Frontiers in Pharmacology” This review evaluates the potential of natural products and medicinal plants for myocardial infarction treatment, highlighting their therapeutic promise and mechanisms such as reducing oxidative stress and inflammation, but reports no new clinical results.
9 citations
,
December 2022 in “Phytomedicine” This review discusses the pharmacology, toxicology, and clinical efficacy of flavonoids and saponins, highlighting the need for more data on their pharmacokinetics, interactions, and toxicities as most research is still in vitro.
9 citations
,
March 2019 in “Molecular & cellular proteomics” In this study, around 1% of proteins in skin fibroblasts significantly changed in response to reductive stress, affecting collagens and MAPK signaling pathways.
9 citations
,
January 2022 in “Biology” This study concluded that male mice are more susceptible to valproic acid-induced autism spectrum disorder than female mice, with noticeable differences in brain histoarchitecture and receptor protein levels.
8 citations
,
September 2021 in “EMBO Molecular Medicine” This study found that a 5-mer peptide called P5 promotes hair growth by activating adiponectin receptor 1, suggesting its potential use as a topical treatment for alopecia.
8 citations
,
January 2019 in “Turkish journal of medical sciences” This study found that ischemia-modified albumin (IMA) may be a promising biomarker of oxidative stress in patients with alopecia areata, offering better potential compared to other oxidative stress markers.
7 citations
,
August 2023 in “Life” This review discusses using extracellular vesicles as less invasive surrogates for assessing drug-metabolizing enzymes and transporters, suggesting potential advancements in precision therapy, but reports no new clinical results.
7 citations
,
January 2023 in “Journal of Hematology & Oncology” This review discusses how targeting protein degradation processes may help overcome cancer drug resistance, but reports no new clinical results and suggests further research for precise therapeutic strategies.