Research Relevant Conditions and Pathology in Nonhuman Primates

The document reviewed the use of nonhuman primates (NHPs) in biomedical research, highlighting their value due to their close genetic relationship to humans and similar disease responses. It discussed how spontaneous and incidental histopathologic changes in NHPs, influenced by factors like species, genetics, age, and geography, can complicate study results. These background changes, often exacerbated by experimental conditions such as xenobiotic treatments, pose challenges due to the limited number of NHPs used in research. The review aimed to enhance the interpretation and validity of studies involving various NHP species, including macaques, baboons, and monkeys, by summarizing research-relevant conditions and pathologies.