TLDR Certain gene variants are linked to severe acne, especially in males.
This study examined the association of androgen-related genes CYP21A2 and CYP19A1 with severe acne vulgaris in 1,252 Han Chinese individuals, including 600 patients and 652 controls. Significant associations were found between severe acne and SNPs in the CYP21A2 gene, particularly rs6474 and rs6465, with rs6474 linked to a higher risk and rs6465 having a protective effect. In males, SNPs in both CYP21A2 and CYP19A1 were associated with severe acne, with specific haplotypes influencing risk levels. No significant associations were found in females. The study suggested that genetic variations in these genes might affect androgen and estrogen levels, contributing to acne susceptibility, and highlighted the need for further research to understand these genetic mechanisms.
124 citations
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July 2012 in “Archives of Dermatological Research” Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
77 citations
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April 2009 in “British Journal of Dermatology” Aromatase gene variation may increase female hair loss risk.
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January 2009 in “Medicine” Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.
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December 2004 in “Annals of the New York Academy of Sciences” Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.
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March 2019 in “British Journal of Dermatology” Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.
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November 2022 in “Frontiers in immunology” Sebaceous glands play a key role in skin health, immunity, and various skin diseases.
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September 2017 in “Molecular and Cellular Endocrinology” Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.
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December 2022 in “Frontiers in Endocrinology” Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.
16 citations
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September 2008 in “Dermatologic Therapy” CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.
