10 citations
,
March 2021 in “Clinical Cosmetic and Investigational Dermatology” This study found that specific genetic variants in the CYP21A2 and CYP19A1 genes were associated with severe acne vulgaris among Han Chinese, particularly in male patients.
8 citations
,
September 2018 in “Journal of Cosmetic Dermatology” This study found that serum irisin levels were significantly lower in patients with acne vulgaris compared to healthy controls and were negatively correlated with insulin resistance and disease severity.
April 2026 in “Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi” This study found that patients with severe acne vulgaris had different systemic inflammatory indices and hematologic parameters compared to healthy individuals.
10 citations
,
January 2017 in “Dermatology Online Journal” This review found that metformin was an effective adjunct therapy for treating moderate-to-severe acne vulgaris in patients without polycystic ovary syndrome or androgen excess.
November 2025 in “Journal of Multidisciplinary Healthcare” This study found that combining fire needle therapy with DHT treatment over eight weeks improved lesion severity, scar symptoms, quality of life, and reduced serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.