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In this study, compound glycyrrhizin promoted hair regrowth in a testosterone-induced alopecia mouse model and increased human hair dermal papilla cell proliferation, likely through activating the Wnt/β-catenin pathway.

In this study, the authors reported that AtRXR3, a phosphorus-inducible DUF506 protein, modulates root hair growth under phosphorus stress by interacting with calmodulin and influencing calcium oscillations.

This study introduces genital sex differentiation parameters (GSDP) to analyze sexual differences in external genitalia and perineum development in mice, revealing varied sensitivity to androgen inhibition in genital structures.

This review covers the role of proteoglycans in tissue growth and regeneration and highlights several studies on their potential as therapeutic targets, but reports no new clinical results.

This review discusses the role of LGR4 in tumors, highlighting its involvement in cancer progression, metastasis, and chemotherapy resistance, as well as its regulatory effects on tumor stem cell self-renewal and stem cell characteristics, based on multiple recent studies.

In this study, TRPV1 signaling was found to play a critical, previously unrecognized role in human sebocyte biology, and targeting this pathway may offer a new approach for managing inflammatory sebaceous gland disorders like acne.

This study found that a human relevant potency threshold for estrogen receptor alpha agonism may serve as a health-protective screening tool, and highlights inference performance as essential for scientific confidence frameworks.

New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.

This review discusses newly identified non-Edg family lysophosphatidic acid receptors, detailing their roles in vascular development, platelet activation, and hair growth, and reports no clinical results.

In this study, transgenic mice overexpressing the glucocorticoid receptor in certain epithelia showed skin development abnormalities resembling ectodermal dysplasia and exhibited reduced inflammatory responses.

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.

This study suggests that Mrp3 may play a role in both wound healing and the hair follicle cycle as a growth factor and/or angiogenesis factor.

This study created transgenic mouse models with the LMNA gene mutation common in Hutchinson-Gilford progeria syndrome, revealing skin and teeth abnormalities related to transgene expression levels.

In this study, researchers demonstrated that in a mouse model, the stimulation of mammary tumor growth due to progesterone is primarily caused by its metabolite, 5αP, not progesterone itself.

This study found that a lower number of GGC sequences in the androgen receptor gene was associated with better clinical response to finasteride in male androgenetic alopecia patients.

This study found that bursts of ERK activation in the epidermis of mice were linked to cell division, supporting synchronized cell proliferation and transient ERK activity in living tissues.

This study found that inhibiting the enzyme PDE8A can promote adipocyte differentiation and enhance hair growth in an animal model of androgenetic alopecia, suggesting PDE8A as a potential therapeutic target for restoring dermal adipogenesis and hair cycling.

This review discusses the roles of prostaglandins in hair loss and highlights their potential as targets for new alopecia treatments, but reports no new clinical findings.

This study found that transgenic mice expressing cgVEGF164 had increased hair follicle diameter and density, potentially linked to higher phosphorylation levels of ERK1/2, AKT1, and LEF1 proteins.

This study found that the retinoid receptor and PPAR pathway are involved in hair follicle miniaturization in androgenetic alopecia, alongside androgen receptors.

This study concluded that the receptor-like kinase ERULUS, regulated by auxin, is crucial for modulating cell wall composition and pectin dynamics during root hair growth in Arabidopsis.

This study suggests that the GDNF signaling pathway may enhance skin regeneration, as observed in axolotls and Spiny mice, indicating potential for similar processes in humans.

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

This study found that petroleum ether extract of Glycyrrhiza glabra prevented alopecia in testosterone-treated male rats, demonstrating effects comparable to the standard treatment finasteride.

In this study, a novel mutation in the glucocorticoid receptor gene was identified in a young woman, impairing glucocorticoid signaling and leading to generalized glucocorticoid resistance.

In this study, ethanol discontinuation in Y 1 R / LacZ transgenic mice significantly decreased neuropeptide Y immunoreactivity and increased Y 1 receptor gene expression in the amygdala, with evidence suggesting an important role for the progesterone metabolite 3α,5α‐TH PROG in these changes.

This study found significant differences in gene expression, particularly in androgen receptor activity, between men with post-finasteride syndrome and healthy controls, suggesting a potential biological basis for the syndrome.

This study found that OsPHR3 overexpression in rice led to significant tolerance to low-phosphorus stress and normal growth under normal conditions, suggesting its potential for improving phosphorus uptake efficiency.

In laboratory and artificial skin model experiments, this study found that plant-derived PDRN from Korean ginseng effectively promoted skin cell regeneration and strengthened the skin barrier, suggesting a sustainable alternative to animal-derived PDRN.

This review discusses the role of norepinephrine release and protein kinase C activation in the development of benign prostatic hypertrophy, suggesting potential targets for new therapies, but it reports no new clinical results.