27 citations
,
October 2016 in “The Journal of Clinical Endocrinology and Metabolism” In this study, daughters of women with PCOS and control daughters showed no significant differences in metabolic and hormonal parameters, but more PCOS daughters exhibited hirsutism at advanced pubertal stages.
26 citations
,
July 2021 in “International journal of adolescent medicine and health” This review covers various treatments for managing PCOS symptoms and infertility, noting that aromatase inhibitors may be as or more effective than clomiphene citrate for ovulation induction but reports no new clinical results.
24 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review examines hormonal influences on acne development and available hormonal therapies but reports no new clinical results.
24 citations
,
January 2010 in “Annales d'endocrinologie” This review discusses treatment options for hirsutism in women of childbearing age, focusing on the use of contraceptives, CPA, spironolactone, and third-line therapies, and reports no clinical results.
24 citations
,
March 1996 in “Postgraduate Medical Journal” In this study, most women with hirsutism and regular menstrual cycles were diagnosed with polycystic ovary syndrome, suggesting limited use of the term 'idiopathic or racial' hirsutism without thorough evaluation.
23 citations
,
June 1997 in “Baillière's clinical obstetrics and gynaecology” This article discusses various diagnostic categories and treatments for hyperandrogenism, with a focus on polycystic ovary syndrome and reports no new clinical findings, calling for specific treatments and lifestyle changes.
23 citations
,
March 1994 in “Fertility and sterility” This study found that oral contraceptives effectively suppressed hyperandrogenemia in most patients with hyperandrogenic-insulin-resistant acanthosis nigricans syndrome, though GnRH-a therapy was beneficial for those not responding initially.
21 citations
,
April 2016 in “International Journal of Oncology” This study found that treatment with the GnRH agonist Triptorelin significantly decreased invasion and expression of S100A4 and CYR61 in certain breast cancer cells, suggesting a potential role in slowing cancer progression.
20 citations
,
June 2012 in “Human Reproduction” This study observed that pregnant women with polycystic ovarian syndrome had a higher prevalence and incidence of cervical insufficiency compared to those without PCOS.
19 citations
,
March 2022 in “International Journal of Environmental Research and Public Health” This review covers the neuroendocrine aspects of polycystic ovary syndrome, focusing on hormones and neurotransmitters like GnRH and kisspeptin, but does not report new clinical findings.
19 citations
,
December 2021 in “Endocrine Reviews” This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.
19 citations
,
October 2012 in “Frontiers of Hormone Research” This article reviews treatment strategies for ovulation induction in women with PCOS seeking pregnancy, emphasizing lifestyle changes and pharmacological options, and reports no new clinical findings.
19 citations
,
January 1997 in “Dermatologic Clinics” This chapter reviews various antiandrogens and androgen inhibitors, detailing their mechanisms, uses, and side effects, with a focus on spironolactone, finasteride, dutasteride, and oral contraceptives.
18 citations
,
December 2014 in “Obstetrics and Gynecology Clinics of North America” This study suggests that weight loss can improve fertility outcomes in overweight and obese women with PCOS, and letrozole should be considered the new first-line treatment over clomiphene citrate for anovulatory infertility in this population.
18 citations
,
June 2010 in “Current medicinal chemistry” This review discusses current treatment options for hirsutism, emphasizing the importance of combining therapies for better outcomes, but reports no new clinical findings.
17 citations
,
April 2009 in “Andrologia” This case study reports that hormonal imbalances in a young boy with precocious pseudopuberty returned to normal after the removal of a testicular interstitial cell tumor, with normal spontaneous puberty following.
16 citations
,
September 1990 in “Fertility and sterility” This study reported that ketoconazole may effectively normalize menstruation and reduce testosterone and hair growth in women with ovarian hyperandrogenism, though its safety needs further evaluation.
15 citations
,
May 2010 in “Pediatrics in Review” This article reviews the normal and delayed maturation of the HPG axis and pubertal development in boys and girls, emphasizing clinical aspects of diagnosing and managing delayed puberty, but it reports no new clinical findings.
15 citations
,
August 1998 in “Australasian journal of dermatology” This review discusses various treatments for hirsutism, including cosmetic techniques, anti-androgens like spironolactone, and new drugs such as finasteride and flutamide, but it reports no new clinical results.
14 citations
,
January 2018 Lifestyle changes and medical treatments can help manage infertility in women with PCOS.
12 citations
,
October 2004 in “Expert Opinion on Investigational Drugs” This review discusses current and emerging therapeutic strategies for managing polycystic ovary syndrome, emphasizing treatment tailored to individual patient complaints and highlighting the roles of hormone therapy and insulin-sensitizing agents.
11 citations
,
May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology” This review explores the evaluation and treatment of hirsutism, emphasizing a systematic approach to uncovering its causes and recommending combination therapies for effective management, but presents no new results.
10 citations
,
June 2006 in “Fertility and Sterility” This article discusses the diverse symptoms and treatment options for polycystic ovary syndrome, emphasizing diligent management of its metabolic component, but reports no new findings.
9 citations
,
April 2015 in “Dermatologic Therapy” This review discusses the use of hormonal therapies for managing acne vulgaris in adult women and reports no new clinical results, emphasizing the chronic and severe nature of acne in this population.
9 citations
,
January 1997 in “Gynecological Endocrinology” This review discusses the regulation of hair growth, causes of excessive androgen secretion, and current safe solutions for hyperandrogenism manifestations in women but reports no new clinical results.
8 citations
,
February 2021 in “Journal of the American Heart Association” This study observed that medical castration for prostate cancer prolongs the QT/QTc intervals, potentially leading to serious arrhythmias like torsade de pointes and ventricular fibrillation, even in patients without prior QT prolongation risk.
8 citations
,
March 1942 in “Journal of Endocrinology” This study found that growth in rats hindered by thyroid removal at birth can be normalized through the administration of thyroid preparations like thyroxine and artificial thyroprotein.
6 citations
,
November 2015 in “JAMA” This study found that oral contraceptive pills improve mild hirsutism, while flutamide and spironolactone are beneficial for more severe cases, but other therapies show inconsistent or no benefit.
6 citations
,
April 2009 in “Fertility and Sterility” Finasteride helps induce ovulation in nonresponder PCOS women.
6 citations
,
January 1984 in “PubMed” This study found that spironolactone reduced androgenic hormones in hirsute women but had only marginal effects on hair growth, making it no more advisable than other therapies.